“nominally significant”

Model 4 constrains the MZ pair correlation to be twice the correlation for DZ and sister pairs combined, and the comparison of the log-likelihoods with those of Model 2 shows that, except for Cirrocumulus , there was at least nominally significant evidence that the MZ correlations were more than twice the corresponding correlations for DZ and sister pairs combined (all p ≤ 0.05).

When the sample was increased by adding females, 2 additional SNPs were nominally significant ( P < .05).

Out of 27 SNPs, correlation with absolute latitude was nominally significant (p < 0.05) for 13 of them.

A few traits exhibited nominally significant associations ( p < 0.05), but the effect directions were inconsistent across traits and sensitivity analyses (weighted median, MR Egger) did not uniformly support these findings.

Nominally significant ( P < 0.05) associations were observed at nine SNPs in a direction consistent with the established association.

These pathways are potential novel associations with the Target Disease, which we checked by measuring enrichment of nominally significant SNPs (p < 0.05) in those genes from among the Target GWAS.

Seven of the 10 polymorphisms showed nominally significant signals of association with MS (p<0.05) ( table 1 ).

Linear regression analysis revealed nominally significant association ( P < 0.05, without multiple testing correction) between SNPs in the 20 kb region flanking ARC and the visuospatial ability subset, delayed episodic memory, and episodic memory (Table 4 ).

We first used the set-based test feature in PLINK with 100 000 permutations to identify up to 5 SNPs in each gene that were independent of one another ( r 2 <0.5) and nominally significant ( P <0.05).

In addition, we identified a nominally significant negative genetic correlation ( P < 0.05) between depression and the volume of the hippocampus (rG = -0.06, P = 2.00 x 10 -2 ).

Interestingly, a previous GWAS of bipolar disorder in Norwegian individuals followed by replication in Icelandic samples also found nominally significant ( P < 0.05) markers located in this gene area 39 .

Variants with FDR < 0.05 in at least one source were confirmed as nominally significant ( p < 0.05) with consistent effect direction in the other available data sources.

However, nominally significant ( p < .05) genetic correlations with wellbeing‐index phenotype were observed for thickness of right cuneus ( r g = −0.110, p = .028), left rostral anterior cingulate ( r g = −0.112, p = .034) and left insula ( r g = −0.099, p = .037). 3.10 Gender‐stratified associations The result of sex‐stratified association analysis between wellbeing‐index and IDPs is presented in Figure S6 .

To observe overall genetic control of gene expression in a disease context, we intersected all cis-eQTL results with the nominally significant GWAS SNPs ( p < 0.05) [ 8 ] and plotted the p values from the two sets (Fig. 2 ).

Results: In study 1, four SNPs showed nominally significant association ( P ≤0.05) with OS; two of these SNPs (rs1126647, rs4073) in IL8 were associated ( P ≤0.05) with OS in study 2.

To investigate whether eQTLs are overrepresented in associations found in the published DIAGRAM and MAGIC GWAS results, we calculated the enrichment of nominally significant ( P ≤ 0.05) GWAS associations among our significant eQTLs using a binomial test ( Table 2 ).

Reoperation and anxiety remained nominally significant ( p < 0.05) but did not retain significance after correction.

The most nominally significant transcripts in P301L included stress-response and glial markers (HSPB1, GFAP, DDIT3; p < 0.05), and in L284L included neuronal activity and disease-associated markers (FOS, ATXN2; p < 0.05) (Fig. 7 b, c, e, f).

Of these, 11 (4.4%) had nominally significant association (p-value < 0.05) with TNFα receptor 2 levels.

The pathway analyses mainly included two libraries, the Small Molecule Pathway Database (SMPDB) [ 57 ] and the KEGG [ 29 ] database, and the significance level of the pathway analysis was nominally significant, i.e., P < 0.05.

To further confirm potential mechanistic associations that are perturbed in IBS, we specifically focused on the subset of associations that were nominally significant ( p- value < 0.05) and changes in the same direction in healthy controls.

PES or PGS with a nominally significant ( P <0.05) G×E term with either UNa + or UK + were then carried forward for additional sensitivity analyses.

Genes showing nominally significant correlations ( P < 0.05) were considered behavior-associated candidates in this exploratory analysis.

After these corrections, the average reference allele frequency at all heterozygous sites was 0.5, and 50.02% of nominally significant ( P < 0.05) allele-specific variants favored the reference allele ( Fig. 1 B).

Genetic pathway analysis We identified a gene set by selecting all genes showing nominally significant expression changes ( P ≤ 0.05) in our data set, and we tested if our gene set was enriched for associative signal with two phenotypes: (i) hippocampal volume in adults; (ii) antidepressant response.