“nominally significant”

Causal effects were considered nominally significant (suggestive) when the IVW p < 0.05 and sensitivity analyses revealed no contradictory findings.

Post hoc contrasts revealed that REM theta energy shows a negative statistical trend with the response of the anterior–superior hypothalamus (t = −1.81; p = 0.07) and a positive nominally significant association with the response of the posterior hypothalamus (t = 1.90; p = 0.05; Figure 2 A,B).

The conditional analysis shows that 45 (including 42 genes) out of the total 74 (~60.8%) unique associations are still nominally significant when conditioned on known GWAS variants ( p < 0.05, Supplementary Table S4 ).

However, in successive models of Model 3 and 4 (addition of POAG established and suspected risk factors), and Model 5 (further adjust for co-morbidities), we observed that while no metabolite exhibited significance at the NEF < 0.2 level (except for LPC(16:0) in Model 3), all were nominally significant and the direction of associations for the metabolites was similar ( p < 0.05).

We defined this set as cis -eQTLs identified in LCLs or transformed fibroblasts in GTEx ( FDR < 0.05), which were not even nominally significant ( P > 0.05) in GTEx breast tissue.

Nominally significant interactions ( P <0.05) were found for genetic variants in MVK , LIPC , PABPC 4, AMPD 3 with change in high‐density lipoprotein cholesterol; SPTLC 3 with change in low‐density lipoprotein cholesterol; TOM 1 with change in total cholesterol; PDXDC 1 and CYP 26A1 with change in triglycerides; and none for lipoprotein (a).

Despite limited overlap at the single-metabolite level between the two overall OC outcomes, we observed greater concordance at the pathway level: among nominally significant pathways (raw p < 0.05), arginine and proline metabolism and beta-alanine metabolism overlapped across the two outcomes ( Figure 1 E; Supplementary Table S4 ).

Furthermore, these variants exhibited directionally concordant and nominally significant associations ( p < 0.05) with glycated hemoglobin levels in the UK Biobank ( n = 344,182) [ 34 ].

To test for parallel patterns of gene expression, we first filtered potential candidate genes based on a nominally significant slope (either positive or negative at P < 0.05) between ornament size and gene expression (normalized transcript counts; Dataset S6 ).

Only 10 of the 100 random gene sets showed a nominally significant result (p<0.05) whichever test statistic was used (SUMSTAT or SUMSQ).

In most of the environment–disease relationships, the models were well calibrated, with the calibration coefficients being nominally significant in 8 and 7 out of 8 relationships in the UKB and BBJ, respectively ( P < 0.05).

All were nominally significant (P < 0.05).

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.

No variables nominally significant in one immune mediator (0.01 < P < 0.05) would survive multiple testing correction.

Model 4 constrains the MZ pair correlation to be twice the correlation for DZ and sister pairs combined, and the comparison of the log-likelihoods with those of Model 2 shows that, except for Cirrocumulus , there was at least nominally significant evidence that the MZ correlations were more than twice the corresponding correlations for DZ and sister pairs combined (all p ≤ 0.05).

All 15 representative traits remained nominally significant (p<0.05) and showed consistent effect directions between marginal and conditional analyses ( Supplementary file 1 ).

A FDR-adjusted P value < 0.05 was considered statistically significant; unadjusted P value < 0.05 was considered nominally significant and unadjusted P value = 0.05 was considered borderline significant.

After these corrections, the average reference allele frequency at all heterozygous sites was 0.5, and 50.02% of nominally significant ( P < 0.05) allele-specific variants favored the reference allele ( Fig. 1 B).

Two associations ( NDST4 and ASD; RORB and childhood autism) of the three that were nominally significant ( P -value ≤ 0.05) in the original analyses remain so.

In addition, we identified a nominally significant negative genetic correlation ( P < 0.05) between depression and the volume of the hippocampus (rG = -0.06, P = 2.00 x 10 -2 ).

Nominally significant ( P < 0.05) associations were observed at nine SNPs in a direction consistent with the established association.

Although hypofractionation (hypofractionation or extreme hypofractionation versus conventional fractionation) was nominally significant for rectal bleeding on univariate analysis ( P = .05), it did not remain significant independently of the inclusion of the BED V55Gy cutoff point (OR, 3.6; P = .08).

We first used the set-based test feature in PLINK with 100 000 permutations to identify up to 5 SNPs in each gene that were independent of one another ( r 2 <0.5) and nominally significant ( P <0.05).

Overall, we found nominally significant associations ( P -value < 0.05) with exons common to the intermediate and short transcripts (Table 2 ).

In the meta- analysis of pilots, flight attendants, and nurses ( n = 59), three of these CpG sites presented nominally significant association ( p < .05) so that cg04188238 and cg12896146 showed higher methylation levels in association with the A allele of rs12506228 (cg04188238 β = 0.148, p = .0075, p Bonferroni = .114; cg12896146 β = 0.15, p = .019, p Bonferroni = .264) and cg10063179 lower methylation levels (β = −0.141, p = .0048, p Bonferroni = .074) ( Figure 4 , Supplementary Table S6).