Biologically Effective Dose and Rectal Bleeding in Definitive Proton Therapy for Prostate Cancer.

However, the BED V55 Gy remained highly significant, even when controlling for fractionation in the multivariate model (OR, 9.81; 95% confidence interval [CI], 2.4-40.5; P = .002).

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Although hypofractionation (hypofractionation or extreme hypofractionation versus conventional fractionation) was nominally significant for rectal bleeding on univariate analysis ( P = .05), it did not remain significant independently of the inclusion of the BED V55Gy cutoff point (OR, 3.6; P = .08).

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