“nominally significant”

When Li treatment response phenotypes in bipolar patients was screened by a large (1,693 sequence) genome-wide association study of pre-miRNA genes plus 20 kb flanking sequence, only one pre-miRNA gene had a nominally significant (p ≤ 0.05) sequence variation association, but when corrected for multiple comparisons, no polymorphisms in pre-miRNA plus flanking sequence showed any association with Li treatment phenotypes 91 .

We found 13 taxa with nominally significant ( P < 0.05) associations with OA case status, but none of the associations remained significant after adjustment for multiple comparisons.

For the first regression analysis, the interaction model term Group (DS versus TD)x Age, comparing the relationship between volume and age between DS and TD groups, remained significant after Bonferroni correction for the left superior parietal lobe, and in all other ROIs found significant in primary analyses, the interaction term was nominally significant at an unadjusted P < .05.

List of all FDR significant DE ncRNAs at FDR < 0.05 as well as the nominally significant DE ncRNAs (P < 0.05) for both ileal and rectal biopsies are provided in Additional file 4 : Table S3.

The associations supported by more than 1,000 cases and significant effects at a p -value of <0.001 were graded as “recommended.” Nominally significant associations ( p < 0.05) were considered weak evidence.

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

In contrast, the waiting group exhibited nominally significant within-group longitudinal changes in FC for 10 channel pairs before FDR correction (paired t -tests: 0.01 < p < 0.05), visualized in Figure 5 C.

The primary reason for the nonreplicated pQTLs is the limited size of the replication cohort: of 70 pQTLs that had 80% replication power, 58 (82.9%) replicated and most (36 out of 38) of the nominally significant ( P < 0.05) pQTLs had concordant directionality, suggesting that most of the unreplicated pQTLs should be replicable in future larger-scale studies.

We considered a SNP-lipid association to be validated if (i) the SNP was significantly associated ( P < 5 × 10 −8 ) in the unadjusted BHS discovery GWAS; (ii) the direction of effect was concordant between the validation meta-analysis and the BHS discovery analysis; and (iii) the association was nominally significant ( P < 0.05; less conservative) or reached the Bonferroni significance threshold ( P < 2.34 × 10 −5 ) in the validation meta-analysis.

SNPs that were identified as being shared loci (GWAS-significant loci for BMI or WHRadjBMI and nominally significant (p < 0.05) for basal or stimulated lipolysis) were used as the exposure.

HMOX1 induction is nominally significant in HNSC (Wilcoxon p-value <0.05), and is not significant in UCEC or BLCA.

Using TDT, we identified eight nominally significant associated SNPs ( p =<0.05).

We also evaluated excess significance bias, potentially arising from publication bias or selective reporting, using a chi-square test to compare the observed number of studies with nominally significant results ( p < 0.05) against the expected number.

Nominally significant differences (uncorrected p < 0.05) were observed at Cz, T4, and O2 electrodes in a narrow time range between 449 and 487 ms; however, we observed more positive values in CTLs, compared to NMS, whereas the opposite pattern was observed in the original study ( Fig. 1 /C ). 3.3 HEP during REM in nightmare and control participants: Study 2 The comparison of HEP during REM sleep did not yield significant differences across NMs and CTLs in Study 2 ( Fig. 1 /B ).

Six variants (rs1260326, rs4410790, rs6968554, rs6968865, rs17685 and rs6265) were nominally significant ( P < 0.05), while three variants on 7p21 (rs4410790, rs6968554 and rs6968865) were significant after multiple correction ( P < 0.05/11).

A nominally significant causal association was defined as P < 0.05 in the IVW analysis, with consistent effect directions (β) across complementary methods.

Assessment of differentially methylated regions Nominally significant probes ( p ≤ 0.05; n = 24,149) were included in the differentially methylated region (DMR) analysis, identifying 123 DMRs ( q ≤ 0.05; Supplementary Table 5 ).

Nominally significant ( P < 0.05) associations with gout were detected at CARD8 rs2043211 (OR = 1.12, P = 0.007), IL1B rs1143623 (OR = 1.10, P = 0.020) and CD14 rs2569190 (OR = 1.08; P = 0.036) .

We also discuss nominally significant results ( P < .05).

Genetic pathway analysis We identified a gene set by selecting all genes showing nominally significant expression changes ( P ≤ 0.05) in our data set, and we tested if our gene set was enriched for associative signal with two phenotypes: (i) hippocampal volume in adults; (ii) antidepressant response.

The 11bp indel in ASIP known to cause the black base coat colour was not significant ( P >0.05); however, six single nucleotide polymorphisms (SNPs) within the genomic region encoding the ASIP gene and one within MC1R were identified as being nominally significant ( P <0.05) in association with opioid analgesic effectiveness.

Overlap between Life-History Traits Nominally significant genes ( P < 0.05) showing association between root-to-tip ω and each of the life-history traits under study (MLS, female maturity, gestation length, weaning time, and body mass) were retrieved and investigated for overlap.

Most relationships were attenuated when all components were added, with CHD, CHF, and CKD remaining nominally significant predictors ( p < 0.05).

After multiple testing corrections, one of these SNPs was significant (rs73349121, p = 0.0001), 9 were nominally significant ( p < 0.05, with 5 expected), and 58/99 had a direction of effect that was consistent with the Whites-only analyses (one-sided p = 0.04, Fig. 2 ).

Furthermore, a weighted polygenic risk score (PRS) made from the 18 SNPs common between the two datasets showed a nominally significant association ( P < 0.05) with the oral glucose tolerance test derived variables area under the curve (AUC) for insulin, AUC for insulin/AUC for glucose, insulin at 30 minutes and insulin sensitivity index ( S6 Table ).