“nominally significant”

In the scRNA-seq data, a nominally significant decrease in proliferating B cells (unadjusted p -value < 0.05) was also observed when comparing baseline samples with aggregated post-vaccination data (Fig. 5e ).

Three of these proteins were nominally significant ( P < 0.05) and consistent with the direction of effect in the discovery cohort (SFTPB, effect size = 2.35, P = 1.4 × 10 –4 , BPI Fold Containing Family B Member 1 (BPIFB1), effect size = 1.90, P = 0.0075; PPIA, effect size = − 0.79, P = 0.0074; Fig. 1 C).

Although autism GWASs currently provide limited statistical power for these analyses, we observed nominally significant ( p < .05) enrichment of associations in the deep layer excitatory neuron FC-ExN-4 of the frontal cortex and oligodendrocyte precursor Thal-OPC of the thalamus by both MAGMA and SLDSR ( Figure S11 in Supplement 2 ).

When all eight nominally significant SNPs were included in a multiple Cox regression analysis ( n = 5,164), they all remained significant ( P < 0.05) ( Table 3 ).

All nominally significant transcripts identified in the univariate analyses (p≤ 0.05) were used to generate AD-relevant gene co-expression networks.

Therefore, we limited our analyses to GWASs with a nominally significant h S N P 2 ( Z h 2 S N P > 1.64 ; P h 2 S N P < 0.05 ).

For the probe annotated to GABBR1 among the top 1000 DMPs associated with MCI to AD conversion status in the AddNeuroMed study (cg06512249, β = − 0.03, P = 0.003), the direction was consistent with multiple probes in the same region from this study (cg03316098, β = − 0.05, P = 0.01; cg10234998, β = − 0.10, P = 0.005; cg12061917, β = − 0.07, P = 0.001; cg21481950, β = − 0.06 P = 0.007) even though cg06512249 did not reach the nominally significant threshold in this study ( P > 0.05) (Additional file 1 : Fig. 8E).

In the MAGMA gene-property analysis, the abundance of hsCRP-associated genes expression was nominally significant in the liver and blood tissues ( P < 0.05, Fig S7) .

When Li treatment response phenotypes in bipolar patients was screened by a large (1,693 sequence) genome-wide association study of pre-miRNA genes plus 20 kb flanking sequence, only one pre-miRNA gene had a nominally significant (p ≤ 0.05) sequence variation association, but when corrected for multiple comparisons, no polymorphisms in pre-miRNA plus flanking sequence showed any association with Li treatment phenotypes 91 .

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

There were nominally significant associations of complement component 3 with PET amyloid, and apolipoprotein(a), apolipoprotein A-I, ceruloplasmin, and PPY with MCI conversion to AD (all P < 0.05).

Moreover, sensitivity gene-burden tests considering only those additional carriers identified by WGS (that is, not identified by WES data), 16 of the 23 gene masks with at least five carriers showed a nominally significant association ( P < 0.05) with the target phenotype, indicating that the additional coding variants identified by WGS are likely to be functionally relevant.

Out of these, 12 demonstrated nominally significant associations with the EC 50 of DOX ( p < 0.05; Table 2 ).

We report nominally significant associations ( p < 0.05) and FDR-corrected p-values.

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

All nominally significant associations ( p ≤ 0.05) with BPD or a BPD-related phenotype were considered for replication analysis in our study.

We also annotated whether the association reported in each meta-analytic estimate was nominally significant at a P < 0.05 level as well as at a P < 0.005 level.

Among the top 10 features associated with schizophrenia, we identified three instances of feature-to-schizophrenia risk causal flow with nominally significant p-values (p < 0.05), and six instances in the opposite direction.

After calculating Spearman’s correlation coefficients and correcting for the effect of study center, we identify 30 species and 49 pathways with nominally significant association to the BPDAI score (p < 0.05) ( Figure S3 ).

The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant ( p < 0.05) individual associations with ΔHR.

We found 13 taxa with nominally significant ( P < 0.05) associations with OA case status, but none of the associations remained significant after adjustment for multiple comparisons.

For the first regression analysis, the interaction model term Group (DS versus TD)x Age, comparing the relationship between volume and age between DS and TD groups, remained significant after Bonferroni correction for the left superior parietal lobe, and in all other ROIs found significant in primary analyses, the interaction term was nominally significant at an unadjusted P < .05.

List of all FDR significant DE ncRNAs at FDR < 0.05 as well as the nominally significant DE ncRNAs (P < 0.05) for both ileal and rectal biopsies are provided in Additional file 4 : Table S3.

In contrast, the waiting group exhibited nominally significant within-group longitudinal changes in FC for 10 channel pairs before FDR correction (paired t -tests: 0.01 < p < 0.05), visualized in Figure 5 C.

We considered a SNP-lipid association to be validated if (i) the SNP was significantly associated ( P < 5 × 10 −8 ) in the unadjusted BHS discovery GWAS; (ii) the direction of effect was concordant between the validation meta-analysis and the BHS discovery analysis; and (iii) the association was nominally significant ( P < 0.05; less conservative) or reached the Bonferroni significance threshold ( P < 2.34 × 10 −5 ) in the validation meta-analysis.