“nominally significant”

Using TDT, we identified eight nominally significant associated SNPs ( p =<0.05).

The primary reason for the nonreplicated pQTLs is the limited size of the replication cohort: of 70 pQTLs that had 80% replication power, 58 (82.9%) replicated and most (36 out of 38) of the nominally significant ( P < 0.05) pQTLs had concordant directionality, suggesting that most of the unreplicated pQTLs should be replicable in future larger-scale studies.

In contrast, the waiting group exhibited nominally significant within-group longitudinal changes in FC for 10 channel pairs before FDR correction (paired t -tests: 0.01 < p < 0.05), visualized in Figure 5 C.

When all eight nominally significant SNPs were included in a multiple Cox regression analysis ( n = 5,164), they all remained significant ( P < 0.05) ( Table 3 ).

Of the 87 associations, 79 are with markers present in two or more populations and of these, 19 show nominally significant heterogeneity ( P < 0.05).

In brain (ROS/MAP, n = 515), four of 45 CpGs having one or more nearby transcripts were related to nearby gene expression at FDR < 0.05, and 11 (24%) showed nominally significant (p < 0.05) associations with expression ( Supplementary Table 8 ).

Module genes as candidates for schizophrenia A substantial proportion of the 205 module genes had nominally significant P values (defined as P <0.05 without multiple testing correction) in the corresponding GWAS dataset: 139 module genes (67.80%) had P GAIN <0.05, and 125 module genes (60.98%) had P ISC <0.05.

Genetic pathway analysis We identified a gene set by selecting all genes showing nominally significant expression changes ( P ≤ 0.05) in our data set, and we tested if our gene set was enriched for associative signal with two phenotypes: (i) hippocampal volume in adults; (ii) antidepressant response.

Sex had no significant effect on the KDEF ( p > 0.05), but we found nominally significant sex differences on the FET ( p < 0.05) and a non-significant trend on the RMET ( p = 0.06), such that males performed marginally worse than females.

Local genetic correlations LAVA analysis of 19 loci shared between ASD and INT revealed three loci (2q12.1, 5q22.3 and 14q32.33) with significant local heritabilities ( p < 0.05/19) in both ASD and INT and nominally significant local genetic correlation ( p < 0.05) (marked with green in Table S 3 ), all being positive.

Gene-based analyses indicated three genes with nominally significant p-values (uncorrected p < 0.05) across multiple cohorts: GALC , SEC23IP and PARP9 .

Nominally significant ( P < 0.05) associations with gout were detected at CARD8 rs2043211 (OR = 1.12, P = 0.007), IL1B rs1143623 (OR = 1.10, P = 0.020) and CD14 rs2569190 (OR = 1.08; P = 0.036) .

We also found evidence of enrichment of positive effects of OCAA on both risk factors (81.1%) and disease (73%), with 43.3% and 22.3% being nominally significant (one sided p<0.05), respectively.

However, these genes were only nominally significant ( p < 0.05) and did not reach the transcriptome-wide significance threshold of FDR < 0.1.

Assessment of differentially methylated regions Nominally significant probes ( p ≤ 0.05; n = 24,149) were included in the differentially methylated region (DMR) analysis, identifying 123 DMRs ( q ≤ 0.05; Supplementary Table 5 ).

Nominally significant differences (uncorrected p < 0.05) were observed at Cz, T4, and O2 electrodes in a narrow time range between 449 and 487 ms; however, we observed more positive values in CTLs, compared to NMS, whereas the opposite pattern was observed in the original study ( Fig. 1 /C ). 3.3 HEP during REM in nightmare and control participants: Study 2 The comparison of HEP during REM sleep did not yield significant differences across NMs and CTLs in Study 2 ( Fig. 1 /B ).

Five of the 19 SNPs demonstrated a nominally significant association with neovascular AMD (P < 0.05), of which two (rs3173798 and rs3211883) withstood Bonferroni correction for multiple testing (rs3173798, nominal P = 9.96 × 10−4, allele-specific odds ratio = 0.55; rs3211883, nominal P = 2.09 × 10−4, allele-specific odds ratio = 0.50).

To underpin this, we further checked the directions of effect of all nominally significant a-DMSs ( P < 0.05) and found that methylation changes tended to be negatively associated with maternal smoking between 0 and 4/5 years (Fig. 4b ) and, moreover, that 721/971 (74.2%) a-DMSs showed a stronger decrease in methylation levels from 0 to 4/5 years (Additional file 1 : Table S7).

Combinations demonstrating nominally significant inter-group differences ( p < 0.05) were selected for further exploratory analyses (n = 25 for 3-antigen, n = 31 for 4-antigen, and n = 25 for 5-antigen combinations).

In addition, a nominally significant difference was found for the neuroendocrine parameters stress CORT and increase in CORT as measured in the HPA-RT in males (p < 0.05), but not females.

The IVW method is applicable when horizontal pleiotropy does not exist ( 28 ); If the results of the MR analysis are nominally significant ( P < 0.05), we consider a possible causal relationship between the exposure and the outcome ( 29 ).

Under the assumption that the gap statistic follows a standard normal distribution, approximate p-values for all three analyses were nominally significant (p < 0.05), with the blood and dura analysis resulting in the most significant gap statistics (p < 1×10 -10 ).

Overlap between Life-History Traits Nominally significant genes ( P < 0.05) showing association between root-to-tip ω and each of the life-history traits under study (MLS, female maturity, gestation length, weaning time, and body mass) were retrieved and investigated for overlap.

For all nominally significant associations ( p < 0.05), effect sizes were strongly correlated when using imputed vs.

However, identified correlations were only nominally significant without multiple testing correction ( P < 0.05; Supplementary Table 27 ).