“nominally significant”

Three MR models (IVW, weighted median, and GSMR) demonstrated nominally significant ( p < 0.05) causal effect of IPF on CAD, with the estimated liability-scale odds ratios (ORs) ranging from 1.08 to 1.38 (Table 2 ).

Plasma NFL alone (Pathway 3) showed nominally significant mediation effects for ADAS13, CDRSB, MEM, and LAN (total indirect effect: all uncorrected P < 0.05) ( Figure 2IV .A, B; Table S9); however, after FDR correction, only the mediation effect on MEM remained significant ( P < 0.05).

Furthermore, a weighted polygenic risk score (PRS) made from the 18 SNPs common between the two datasets showed a nominally significant association ( P < 0.05) with the oral glucose tolerance test derived variables area under the curve (AUC) for insulin, AUC for insulin/AUC for glucose, insulin at 30 minutes and insulin sensitivity index ( S6 Table ).

We provided detailed RegulomeDB annotations in relevant cell types (e.g., hematopoietic multipotent progenitor cells, CD34+ hematopoietic progenitor cells, any primary B-cell, lymphoblastoid cell lines from 1000 Genomes [i.e., GM19238], K562, NAMALWA, BLaER1) for: (a) all index variants; and (b) credible set variants with nominally significant ( P < 0.05) functional probability scores.

Three other types of cancer (ESCC, GC and RCC) showed nominally significant associations (P < 0.05).

Resulting group-level oscillations were nominally significant (G-cosinor p < 0.05) in 5.9% to 85.8% of ROIs across seven of the nine MRI metrics (Supplementary Table 4 ).

We report nominally significant associations ( p < 0.05) and FDR-corrected p-values.

We find a nominally significant ( p < 0.05), but not Bonferroni-significant, association of higher levels of (standardized) urea with shorter duration of symptoms, assuming a Weibull distribution for survival times.

SAS (v9.4, SAS Institute, Cary, NC, USA) was used for the statistical analyses with a nominally significant level of P <0.05.

Canonical pathway enrichment analysis revealed nominally significant over-representation of eight pathways (unadjusted p < .05) ( Table S17 ).

It is worth noting that for MD phenotypes and childhood body fatness, the associations with V remained nominally significant ( P < 0.05) if we further adjust for BMI and PD in the SNP-set test.

1815 genes were found to be differentially expressed at a nominally significant level (p<0.05); 809 decreased in expression in the KD samples, while 1106 increased.

Moreover, sensitivity gene-burden tests considering only those additional carriers identified by WGS (that is, not identified by WES data), 16 of the 23 gene masks with at least five carriers showed a nominally significant association ( P < 0.05) with the target phenotype, indicating that the additional coding variants identified by WGS are likely to be functionally relevant.

When all eight nominally significant SNPs were included in a multiple Cox regression analysis ( n = 5,164), they all remained significant ( P < 0.05) ( Table 3 ).

We focus the discussion on correlations that were nominally significant (uncorrected P < 0.05).

There were nominally significant associations of complement component 3 with PET amyloid, and apolipoprotein(a), apolipoprotein A-I, ceruloplasmin, and PPY with MCI conversion to AD (all P < 0.05).

When Li treatment response phenotypes in bipolar patients was screened by a large (1,693 sequence) genome-wide association study of pre-miRNA genes plus 20 kb flanking sequence, only one pre-miRNA gene had a nominally significant (p ≤ 0.05) sequence variation association, but when corrected for multiple comparisons, no polymorphisms in pre-miRNA plus flanking sequence showed any association with Li treatment phenotypes 91 .

Given that five exposures and four analysis methods were included in this study, we consider a significant causal effect at the threshold of p < 0.0025 (Bonferroni correction p = 0.05/20) and nominally significant results at p < 0.05.

Enrichr analysis Zebrafish genes identified in the RNA-seq analysis that showed nominally significant ( p < 0.05) expression change between WT and mgt −/− samples were converted to their human orthologues using the HUGO Gene Nomenclature Committee (HGNC) HCOP tool and the ZFIN database [ 45 ].

Among all the allele contrast meta-analysis, 21 (30%) polymorphisms in 19 genes showed nominally significant associations with HCC risk ( P-value < 0.05).

Although autism GWASs currently provide limited statistical power for these analyses, we observed nominally significant ( p < .05) enrichment of associations in the deep layer excitatory neuron FC-ExN-4 of the frontal cortex and oligodendrocyte precursor Thal-OPC of the thalamus by both MAGMA and SLDSR ( Figure S11 in Supplement 2 ).

All nominally significant transcripts identified in the univariate analyses (p≤ 0.05) were used to generate AD-relevant gene co-expression networks.

Therefore, we limited our analyses to GWASs with a nominally significant h S N P 2 ( Z h 2 S N P > 1.64 ; P h 2 S N P < 0.05 ).

For the probe annotated to GABBR1 among the top 1000 DMPs associated with MCI to AD conversion status in the AddNeuroMed study (cg06512249, β = − 0.03, P = 0.003), the direction was consistent with multiple probes in the same region from this study (cg03316098, β = − 0.05, P = 0.01; cg10234998, β = − 0.10, P = 0.005; cg12061917, β = − 0.07, P = 0.001; cg21481950, β = − 0.06 P = 0.007) even though cg06512249 did not reach the nominally significant threshold in this study ( P > 0.05) (Additional file 1 : Fig. 8E).

We considered a SNP-lipid association to be validated if (i) the SNP was significantly associated ( P < 5 × 10 −8 ) in the unadjusted BHS discovery GWAS; (ii) the direction of effect was concordant between the validation meta-analysis and the BHS discovery analysis; and (iii) the association was nominally significant ( P < 0.05; less conservative) or reached the Bonferroni significance threshold ( P < 2.34 × 10 −5 ) in the validation meta-analysis.