“nominally significant”

Given the small sample size, this analysis was designed as an exploratory approach, where whilst no miRNA survived FDR corrections for multiple testing ( P adj > 0.05), nominally significant miRNAs ( P < 0.05) were examined to identify potential biomarker candidates.

Table 3 shows results for the interaction between all SNPs and medications that showed at least a nominally significant (p < 0.05) SNP* medication interaction, namely thiazides and loop diuretics.

For these sites, we thus see strongest evidence that methylation level correlates with educational attainment beyond effects of own smoking behaviour; however, we note that when taking all 58 top sites, effect sizes in never-smokers were strongly correlated with effect sizes in the entire population (r = 0.83), were in the same direction at 57 sites, and were at least nominally significant in never-smokers ( p < 0.05) at 27 sites (Fig. 2b ).

Secondly, we estimated genetic correlations between each of the traits with nominally significant (p<0.05) univariate values.

Nine (35%) reported nominally significant summary results at P < 0.05 (2 had P < 0.001).

DHX58 and SWAP70 showed protein‐level associations with CAD (FDR <0.05) and colocalization probabilities between 0.5 and 0.7, with nominally significant associations ( P <0.05, unadjusted) at the methylation and expression levels.

Nominally significant predictive improvements ( LRT-p < 0.05) of fitting PRS GxE , over the PRS D effect alone, using summary statistics generated from both UKB and GS were detected for schizotypal personality, heart diseases and chronic obstructive pulmonary disease (COPD) by proxy (Fig. 3b ).

For instance, rs10986600, significantly associated in EUR on chromosome 9, was nominally significant ( P < 0.05) with same effect direction in AFR (0.04) and AMR (0.03) and significant in the multi-ancestry meta-analysis.

By removing each SNP from the MR analysis sequentially, if the association is no longer nominally significant ( P > 0.05) with the SNP removed, this indicates that a particular SNP is driving the association.

Fourth, a nominally significant association (p-value < 0.05) was considered “weak” evidence.

Results: Among the 5 subjects, there were 132 nominally significant correlations (p< 0.05) between mRNA expression and MRI activity.

Using the GSE21032 hypoxia-associated genes there were 5,348 drugs with negative z-scores, of which 2,405 were nominally significant ( p < 0.05).

Among these results, we identified three additional genes with nominally significant differential expression ( P < 0.05) in both the qPCR study and BA10 microarray data as well as a consistent direction of effect (GRM5, NSF, SNCA, Fig. 3 ).

This analysis initially identified 216 KO genes with nominally significant differential abundance (nominal p < 0.05) between healthy and diseased rhizosphere samples.

Nominally significant items/reasons (P < 0.05) are highlighted.

However, the ADL scale had a nominally significant ( p ‐value <0.05) association with total cerebellar volume and cervical spinal cord CSA (Table S4 ).

236 (68.6%) of these 344 CpGs were nominally significant ( p < 0.05) in our study, while 22 (6.4%) remained significant after accounting for the multiple tests of the replication effort ( p < 0.05/344 ~ 0.0001) (Table 2 ).

Nominally significant findings ( P < .05) that did not meet these thresholds were reported cautiously.

In total, 116 associations were identified to be associated with AF at the nominally significant level ( p < 0.05, Supplementary Table S4 ).

4 , 5 , 6 In brief, associations that presented nominally significant random-effects summary effect sizes (ie, P ≤ .05) were graded as convincing (class I), highly suggestive (class II), suggestive (class III), or weak (class IV) evidence ( Table 1 ).

Candidate gene approach None of the imputed variants previously reported as gait speed candidate genes such as ACE , ACTN3, COMT and APOE reached a nominally significant (p<0.05) threshold ( Supplementary Table 3 ).

The association was no longer nominally significant when adjusted for LDL-C levels ( p > 0.05).

Predicted impact of ASC-EV-derived miRNAs on cellular processes The enrichment pathway analyses with the miRNA expression correlations and predicted targets was made by matching the top-60 enriched miRNAs in ASC-EVs with predicted mRNA targets in miRWalk (Suppl data 2 , complete list of nominally significant genes, p-value < 0.05 for each miRNA) and subsequent GO enrichment analyses showed a preponderance for mRNAs affected by miR-1290, miR23/27/24 cluster and the miR-15/107 family with no less than 15,870 mRNAs to be targeted by those enriched ASC-EVs-derived miRNAs.

Both these SNPs were nominally significant (p<0.05) within males and females, however sex did not modify the association.

Of the 87 associations, 79 are with markers present in two or more populations and of these, 19 show nominally significant heterogeneity ( P < 0.05).