“narrowly missed significance”

Furthermore, some factors (histone–MPO, H3Cit, and DNase activity) correlate positively with the growth progression of A.pp in BALF, but narrowly missed significance ( Figures 5E, F, H, I ).

In another placebo-controlled study in patients with symptom duration of <4 weeks and reduced contrast sensitivity, simvastatin (a hypercholesterolemia medication) narrowly missed significance on the primary efficacy outcome (contrast sensitivity), but improvements were noted for VEP latency and amplitude. 58 However, imbalances in randomization and technical issues may have contributed to the observed effects. 59 A study in ON testing possible neuroprotective effects of phenytoin, an anticonvulsant, has recently completed, and another study testing effects of amiloride hydrochlorothiazide, a diuretic, is currently underway.

For ONS volumes, correlation coefficients in the normal ICP subgroup were relatively high and p -values narrowly missed significance.

Since results of radioluminography narrowly missed significance, we decided to divide mice into two groups according to the sum of their tumor volumes and the median tumor volume sum of all mice (A375 pIRES + A375-EphB4 </> 1582.3 mm 3 ).

Additional ADME proteins were differentially expressed but narrowly missed significance, namely the ABC transporter ABCA2, alcohol dehydrogenases ADH4 and ADH6, glutathione S-transferases GSTA2 and MGST3, solute carrier organic anion transporter SLCO1B3 , and the superoxide dismutase SOD3 that tended to be reduced, whereas GSTM1 and the solute carrier SLC22A18 tended to be considerably higher (Fig. 2 B; Supplementary Table 1 ).

This result varied somewhat across permutations of the dFNC analysis, but oscillations were significantly dampened in autism in 5/9 permutations, and narrowly missed significance in 4 more, making it a fairly robust finding ( Fig. 6 ) in the sensitivity analysis, though it did not replicate in test-retest.

S2 and Table S2 ) and narrowly missed significance for women married to patrilateral relatives (OR = 1.07, 95% CI [0.99–1.18]).

Chronic alcohol consumption also altered other mitochondrial processes, elevating TCA cycle intermediates like succinate, citrate, and malate in the EF mouse livers, although malate narrowly missed significance ( Fig. 8 A , supplemental Fig.

Results of a regression analysis indicated that the symptom severity at baseline as well as motor impulsivity were significant predictors in all steps, although motor impulsivity vary narrowly missed significance after applying the FDR correction.

62 , 75 , 76 In MERIT, which randomized patients from Japan, China, and Russia to monthly mepolizumab, the nasal obstruction improved significantly, while the polyp‐size endpoint narrowly missed significance, mirroring the pattern seen in East Asian population subgroups in ANCHOR. 29 , 74 In parallel to CRSwNP, the subgroup analyses for the SWIFT trials for asthma also suggested lower asthma exacerbation rates in East Asian participants, compared with non‐Asian participants despite identical dosing, underscoring the role of population mix. 77 Hence, no conclusion regarding drug superiority can be drawn from the current trials, due to differences across enrollment mixes.

Specifically, positive attitudes increased, and nonacceptance decreased with higher subjective social status, although the post hoc test between the high and low social status groups for the attitudes subscale narrowly missed significance in the unweighted dataset (refer to Multimedia Appendix 1 ).

The ORs for disease risk for each clade B allele, in all cases the minor allele, suggested that the clade B alleles are protective of AD risk in the AS cohort, although in each case the association narrowly missed significance.

Given that our observation of increased remyelination due to increased n-3 PUFA tissue content narrowly missed significance, future mouse studies are also warranted to further establish this effect in a larger cohort of mice in the cuprizone model, as well as in other experimental MS models such as EAE.