Barely Significant
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“may be significant”

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In the literature

Greater age, increased corrected calcium level, decreased TSH level, increased FT4, decreased FT3/FT4 ratio, increased bone-specific alkaline phosphatase, and increased ALT (alanine aminotransferase) may be significant in differentiating apathetic thyrotoxicosis from typical hyperthyroidism, which may aid in accurate diagnosis and treatment ( 7 ).
Apathetic thyrotoxicosis presenting with diabetes mellitus.
J Community Hosp Intern Med Perspect · 2014 · PMC4246146
While a need for further genetic events (second-hit) in the RET gene has also been suggested for cancer development, the role of other factors, such as environmental factors, stochastic events involving also epigenetic modifications, may be significant.
The role of chance in cancer causation.
Med Lav · 2022 · PMC9766839
The anesthetic implications of the basic disease may be significant, such as obstructive airway disease or seizure disorder.[ 24 ] Avoidance of the triggering medication is the cornerstone of treatment of SJS, and the specific as well as the overall list of medications triggering SJS must be borne in mind and avoided [ Table 1 ].
Finally, it is worth noting that Pryor [ 76 ] asserted that if objective differences (between therapeutic modalities) are small, individual preferences and cultural influences may be significant in increasing adherence to treatment and also in the selection of an appropriate regimen or regimens for an individual patient.