Barely Significant
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“may be significant”

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In the literature

The dominant B cell epitopes (S76 and S78) in patients with negative HBsAg may be significant candidates for treatment to achieve a functional cure. 49 During PegIFNα treatment, the proportion of total B cells and plasma B cells in the HBsAg-negative group was higher than that in the HBsAg-positive group, when other factors including age, sex, and treatment duration were completely matched. 50 Durability of HBsAg seroclearance Functional cure is more reflected in the recovery of liver function, especially the specific immune function against HBV, through the maximum long-term suppression of HBV replication, without emphasis on the elimination of integrated HBV DNA and cccDNA.
21 Even so, their distress may be significant, and some may seek orchiectomy as a means of controlling clinically significant symptoms that impair daily function. 14 Properly assessing one’s interest and/or desire for genital ablation can be helpful for providing the best treatment and supports to meet these patients’ needs. 15 Male-to-eunuch
Many paleosols formed by autocyclic processes, while not regionally correlative, may be significant with respect to groundwater flow (e.g., Weissmann and Fogg 1999 ) and contaminant fate and transport both from the perspective of their potential function as a hydraulic barrier and their potential utility to a stratigrapher as a chronostratigraphic surface or marker bed (Catuneanu 2006 ).
However, there are reports suggesting that trauma and the Epstein-Barr virus (EBV) may be significant risk factors. 2 , 3 Since the initial report of renal myopericytoma in 2010, only 12 additional cases have been documented, 4 , 5 , 6 , 7 , 8 , 9 , 10 bringing the total to 13 cases, including the one discussed in this article.