Barely Significant
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“may be significant”

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In the literature

ription medicine misuse in Asia, and the information that is available is largely qualitative or expert opinion based.[ 8 ] There is concern in this geographical region that, due to severe penalties – including the death penalty – for the possession and/or use of classical recreational drugs, there may be significant misuse of prescription medicines, given their availability and the lesser or no penalties associated with their misuse.
18 Although there may be significant heterogeneity when comparing patients undergoing open and minimally invasive TTC fusion, transportal TTC fusion should be considered in patients with significant comorbidities, particularly those with diabetes mellitus, as it leads to low rates of surgical site infections and thereby may reduce the risk of severe complications such as amputations.