“may be significant”

Pathologist experience, and training may be significant predictors; however, this analysis did not consider these factors.

Environmental factors, such as cellular and physical stress, can also influence miRNA expression (Lukiw & Pogue, 2007 ; Mannironi et al., 2013 ; Rocha, 2007 ), and thus there may be significant genotype‐by‐environment (GxE) interactions present, whereby MBSVs are only pathologically relevant within the context of other environmental risk factors for psychiatric disease.

Similarly, FV consumption may be significant due to the rapid effects of increased vitamins and minerals on energy levels and subjective vitality—a key aspect of positive mood [ 106 ]—which can accumulate within days [ 41 , 107 ].

5 Despite their evolution and improvement (integration of advancing parameters such as age, sex, and immunity), 6 , 7 animal models still suffer from interspecies differences, which may be significant in translating data into human physiology. 8 Therefore, a gap remains in clinical trials of drugs for TBI.

Some valuable research areas may not be reflected in the identified hotspots, suggesting that there may be significant topics that require further exploration beyond those highlighted in the current analysis.

In addition the work of Turner et al., ( 46 ) indicated that mutations in cyoA were less attenuating than those in cydA indicating that growth at lower oxygen tension may be significant since cytochrome d is generally expressed at lower oxygen tensions ( 17 ).

Even if delayed results become available within working hours, there may be significant consequences for patient safety.

Although there is only one report of malignant melanoma arising from porokeratosis[ 17 ] so far, in view of the malignant potential of porokeratosis in general, the present report of malignant melanoma in DSAP could be more than an incidental association and hence may be significant.

Therefore, identification and selection of hybrids under graded level of applied P may be significant.

Additionally, this approach may be significant for patients stabilized on high doses of methadone who may not be able to tolerate a traditional buprenorphine induction.

It may be significant that reduced levels of the regulatory cytokines TGF-β and IL-10 have been observed in relatives. 13 In the study by Wither et al. 12 abnormalities were demonstrated in first-degree relatives of SLE patients relating to the proportion of various B and T cell subsets and in the frequency of antinuclear antibody (ANA) positivity.

These findings suggest that the increased proteasome activity may result from the increase in proteasome units and may be significant in the development of tumor proteasome drugs.

This may be significant as our cohort included only patients that had whole genome sequencing as part of their clinical cancer care which tend to be patients that have failed first line chemotherapy or present with an advanced cancer.

This variability may be significant, as costs can differ widely between public and private healthcare settings, as well as across different regions.

This may be significant from the perspective of exercise intolerance seen in ME/CFS as this kinase is responsible for sensing and enabling increased ATP production and maintaining metabolic homeostasis in striated muscle cells in response to increasing demands for energy during exercise (Morales-Alamo and Calbet 2016 ; Trewin et al. 2018 ).

However, there may be significant transmission in villages without cases during the timeframe of the data if the asymptomatic to symptomatic ratio is as high as estimated, but this cannot be discerned from the CARE data since it contains no information on asymptomatic cases.

However, these symptoms might not occur in other diseases, they may be significant in differentiating RCD from appendicitis as a minor criterion.

These are not straightforward additions as there may be significant interactions between risk factors and, although breast density is an independent risk factor for BRCA1 and BRCA2 cancer risk [ 25 ], the density itself may be heritable and may not increase risk in a similar way in the context of family history of breast cancer alone.

Considering that perturbation signal was propagated to regions surrounding the P-loop, such as L4, Q-loop and α4, subtle perturbations in the active site of PTP1B may be significant in global transduction of intraprotein signal [25] .

total health expenditure Step 3: Assess whether there is an association between the risk factor and the GLaMOR generated pandemic mortality data For all countries, regress (=3) the risk factor with the GLaMOR generated data from (1) For all countries, regress (=4) the risk factor with the GLaMOR generated data from (2) Step 4: Examine the relation of the risk factor with the pandemic mortality data Check how the regression coefficients vary between (3) and (4)? For example, if (3) is not significant and (4) is significant, the risk factor may be significant (see the Decision Rule Set (see: Additional file 1 - Technical Appendix) for all possibilities) Check the direction of the association (the regression coefficient 4)) based on the published literature.

Homozygosity for C677T is associated with a reduced risk of colorectal cancer in subjects with good folate status ( Ma et al , 1997 ), suggesting that the impact that folate status has on genomic stability and repair may be significant in the process of malignant transformation and indicating that uracil misincorporation may indeed be an important early cancer biomarker in humans.

This is further demonstrated by the lower log P of selective hits, telling that enthalpic contributions to binding may be significant compared with non-selective fragments.

states that indicates there may be significant levels of exposure in wild deer populations [ 115 ].

There are also plausible causal connections between our data and cellular genetic processes where the electronic properties of DNA may be significant.

Considering that FISS is regarded as a chronic inflammation-associated tumor with histological features that are similar to wound healing, the expression of STAT3 may be significant and plays an important role in tumorigenesis.