Barely Significant
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“may be significant”

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In the literature

Although they commonly occur as part of structural hydrocarbon traps and may be significant for some CO 2 or other gas storage projects within depleted hydrocarbon reservoirs, sealing faults have heretofore received scant attention in the induced seismicity literature.
Sealing faults and fluid-induced seismicity.
Philos Trans A Math Phys Eng Sci · 2024 · PMC11407506
98 Given that controlled trials are highly unlikely, teams embarking on rechallenge should attempt to enrol their patients into the worldwide efforts to understand the aetiologias of CIN and CIA and report their results, ideally including the variables which may be significant; the exact details of the initial neutropenia, concomitant drug use, patient demographics and clinical details including ethnicity and Duffy type as well as the rechallenge titration schedule.
Although further research will be necessary to evaluate the impacts of chronic traffic-related UFPM exposure on cyclists, it is reasonable to assume that adverse impacts from the cumulative effects of repeated short-term exposures to traffic pollution may be significant in those that cycle frequently for longer periods of time.