These changes would be predicted to render the resulting S proteins furin-uncleavable and the consequences for studies of COVID-19 pathogenesis in animal models of disease may be significant.
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In the literature
The authors reported that the alteration in bacterial diversity and the presence of Blastocystis may be significant factors in the pathophysiology of HE, highlighting a need for more research on this subject [ 85 ]. 2.2.
Other covariates may be significant drivers of exposure but were not included in the model precluding full capture of dosing-exposure relationship in this population.
The incidence of malnutrition in hospitalized older adults depends on many factors and, in global assessment, the differences may be significant.
Our findings are important, because understanding specific relationships between FMS and PA may be significant for improving specific skills or a specific PA intensity.
Conclusion With the limits of the present study, both height and weight were found to be significantly correlated with the MMO of Chinese young adults and may be significant predictors of MMO measurement.
Surgical enucleation represents a conservative approach compared to more invasive treatment options; however, the risk of recurrence may be significant.
For example, the closest matches identified pairwise may lead to small differences between items (e.g., six letter words matched with seven letter words); however, if the one-letter differences become systematic, and one list contains shorter words on average, the overall list differences may be significant.
2 Therefore, the change in the analyte to IS peak area ratios may be significant enough to influence the accuracy of quantitation. 8 − 13 Several approaches have been recommended to overcome caveats associated with the use of d -labeled ISs. 12 − 17 Additional sample preparation steps, the use of shallow gradient profiles to achieve adequate separation of analytes from major matrix components eluting with the solvent front, application of atmospheric pressure chemical ionization (APCI) which is less prone to matrix effect than ESI, 2 or using other than d - (i.e., 13 C-, 15 N-, or 18 O-) labeled ISs are examples of these efforts.
Fourth, this study was conducted in a rural non-Hispanic white population, and there may be significant variation in awareness of stroke warning signs and risk factors in other geographic and racial and ethnic communities in the United States.
Therefore, the presence of QVOA wells containing low levels of RNA (i.e., <50 SIV RNA copies/ml or 10 copies/reaction) may be significant in evaluating BrMΦ latent reservoirs for “shock and kill” strategies since low levels of potentially replication-competent latent genomes could contribute to virus rebound.
Not just VO 2 peak is a predictor of survival, but also peak workload (W peak), V E /VO 2 peak (ventilatory equivalent for oxygen, EQO 2 ) and V E /VCO 2 peak (ventilatory equivalent for carbon dioxide, EQCO 2 ) may be significant [ 8 ].
The differences in reactions to these sounds may be significant in terms of cueing the unconscious regions of reactive “survival” limbic, reticular, and autonomic systems for investigating neuronal operating bands in both healthy and disordered (hypo/hyperactive) states.
If the reported plasma BPA concentrations in humans are accurate, the results suggest human exposure is currently underestimated and that there may be significant sources of exposure though non-oral routes.
The factors that significantly improved the reaction time, BSA blocking and EDTA, were carried over to a three-level Box–Behnken DOE study as well as Tris-HCl and Tween 20, which did not show as significant in the factorial experiment but were included in all runs, so their absence may be significant.
Therefore, there may be significant concerns regarding the suitability of surgery for this age group.
Epidemiological study suggests that living in a rural area, drinking well water, farming and exposure to pesticides may be significant risk factors in the development of PD [ 21 ].
These data suggest that CHIP may be significant in cancer by regulating tumor-related proteins.
The inclusion of NUDT5, a protein that affects the proliferation and apoptosis of tumor cells, may be significant for the resolution of some of these concerns.
Therefore, a specific rumen microbiota composition may be significant for satisfying performance of animals.
We further hypothesize that association of asthma risk with methylation and with the interaction between DNA methylation and SNP may be significant at one age but absent at another.
Impact of Chromosomal Inversions on the Overall Replication Program Although we did not observe differences in S phase progression in strains harboring the engineered inversions, the impact of these rearrangements on the replication program may be significant.
Current research indicates there may be significant biodistribution differences between 225 Ac and 177 Lu labeled to certain pharmaceuticals which could result in absorbed dose underestimation.
Although the effect of one protein may be insignificant at low concentrations, the cumulative effect of many non-specialised proteins may be significant.
Specific amino acid sites (n = 15) that may be significant in the evolutionary development of the ruminant horn were identified in the ALOX12B protein.