Barely Significant
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“may be significant”

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A concise evaluation and management strategy for the ill traveler based on careful consideration of possible diagnoses and the prompt institution of appropriate therapies for tropical illnesses is essential, as the potential for morbidity and mortality in ill travelers who suffer missed or delayed diagnosis may be significant.
This may be significant for the immunogenicity of the OVA 323–339 peptide because the MHCII contents in early and late endosomal compartments (pH 5.9 and 4.5, respectively) are low, compared to the intermediate endosome stage (pH 5.2). 13 , 28 Taken together, these observations suggest that loop insertion stabilizes OVA R339T and proteolytic fragments that contain the OVA 323–339 peptide at the stage of endosomal processing where optimal peptide loading of MHCII is believed to occur.
This pH-sensitive release of DOX may be significant because of the acidic microenvironments found in tumor tissues and cell lysosomes. 36 The DL content of DOX in the NDDS, ACNP-DOX-DSPE-PEG2000-anti-CD20 was 20.1%±1.6%, which was less than that for the ACNP-DOX-DSPE-PEG2000 complex (29.8%±2.56%) and the ACNP-DOX complex (31.2%±2.64%), as shown in Table 1 , which may be attributed to the increasing size of the complex, including the additional conjugated antibody.
While this inter-specialty difference also appears to be the case at our institution ( Table 2 ), the overall TB screening rate appears to be higher at our center, suggesting there may be significant variability within an institution as well as across different regions and health systems.