“may be significant”

For large genes such as clag3 , the effect of the residual upstream protein may be significant, yielding either preserved activity or a dominant-negative effect due to protein-protein interactions with the truncated protein.

Given these two facts, it is reasonable to conclude that the magnitude of obesity alone has no substantial effect on the alveolar lipidome, but it is possible that differences identified in the least stringent analyses may be significant with a larger cohort.

While thermal stresses may be significant under field conditions, particularly for large-area patches (1000 × 1000 mm) subjected to wide diurnal or seasonal temperature ranges, their quantification is considered beyond the scope of this investigation and is identified as a priority area for future research.

First, an independent samples t -test was performed to see if there were significant differences between cortical layers in any of the morphological or PSD-95 related parameters, as previous literature demonstrated that there may be significant heterogeneity in morphometric properties of astrocytes between layers ( Langfelder and Horvath, 2008 ).

Moreover, one of the pitfalls in GWAS studies is multiple testing: many candidate polymorphisms are assessed, so associations may be significant by chance, even though their clinical meaning is not clear.

In fact, our review found that preparation in terms of cost and faculty time may be significant and this should be considered prior to implementing the FC model.

Because placental protein 13 is essential for initial placental growth and the modulation of maternal immunoreaction via T-cell and macrophage apoptosis, low quantities of this protein in EXOs may be significant for confirming the diagnosis of PE ( Pillay et al., 2017 ).

There may be significant side effects of a cure or significant burdens placed on those undertaking a cure (travel, lost work, financial cost, particular biological requirements).

Numerous studies have shown that natural flavonoids modify multiple cellular and molecular mechanisms that may be significant in terms of the prevention and treatment of LC.

Although the age, sex, educational level, and working hours may not relate significantly to caregiving burden, longer experience in dementia care, more training in dementia care, and a more positive attitude towards dementia may be significant predictors of lower caregiving burden ( Costello et al., 2019 ; Lee et al., 2013 ).

Although regulatory and phase III expenses for a repurposed drug may be similar to those for a new drug in the same indication, there may be significant savings in preclinical and phase I and II costs.

Conclusion BMI, total blood loss, anesthesia method, and the total amount of local anesthesia may be significant related factors of postoperative complications following orthognathic surgery.

20 , 21 However, there may be significant overlap in disease severity between TSC1 and TSC2 patients, and many individuals with TSC1 mutations have severe multiorgan system involvement.

Additionally, the combination of low NL and high NO 3 − showed the strongest risk association (HR = 2.90; 95% CI: 1.23–6.84), indicating that even in areas with low NL levels but high NO 3 − levels, there may be significant health risks.

(In the actual process of precipitation of macromolecules, effects (a) and (b) may be significant.) In the reversal-of-charge experiments of Bungenberg de Jong (Kruyt, 1949, pp. 227 and 299), the anion affinities to positively charged groups of various proteins (ion fixation effects) decrease in the order: SCN > I > Br > * * * > F, with SCN having the greatest affinity.

Dynamic monitoring of D-dimer levels may be significant for the prognosis of children with MPP.

The liver kinase B1 (LKB1)-dependent activation of AMPK and reduction of mammalian target of rapamycin (mTOR) activity may be significant contributors to the inhibitory effects of metformin on cancer cell growth and proliferation ( 151 ).

However, there are other elements that may be significant in explaining the physicians’ fear of COVID-19, and these may include: adequacy of staff, the working environment, the leadership and management of the hospital, adequacy of resources at the hospital, competency of physicians, the number of patients and acuity.

Even though mesenchymal tumors in the head and neck are often smaller than those in other anatomic regions, complete excision with free margins might be challenging and the recurrence rate may be significant [ 5 ].

In particular, G-box appeared eight times in BjuSUS08 while Box 4 appeared six times in BjuSUS05 , indicating that they may be significant in light responsiveness and photosynthetic product accumulation.

This suggests that HBV may impact the reprogramming of glucose metabolism in hepatocytes, which may be significant in the emergence of hepatocarcinoma linked with HBV [ 103 ].

Any study that evaluates the utility of a prevention study must include a racially diverse population because it is possible that (1) there may still be mechanistic differences by which patients of different racial backgrounds progress to malignancy and (2) there may be significant socioeconomic barriers that effect treatment efficacy in different populations. 3.2.

Among the available subjects, 15 were Ki67-negative and 3 were Ki67-positive, but a p -value of 0.01 suggests the pilot result may be significant, even with the limited sample size.

The higher incidence of aberrant tracheal buds in human embryos compared to the general population suggests that this developmental process may be significant in understanding the origins of a tracheal bronchus.

Because we filtered out many SNVs when calculating the initial inheritance vectors, there may be significant gaps where a crossover event occurs.