Barely Significant
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“may be significant”

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In the literature

Similarly, other publications consider that these contacts during laterality, more than other occlusal factors, have some degree of association with articular and muscular disorders.[ 5 , 10 , 24 , 25 , 26 ] However, it has been reported that this relationship is not clinically significant for chronic TMD symptoms, but may be significant for acute transient symptoms.[ 10 ] Studies with electromyography demonstrate that alterations in occlusal contacts may change the pattern and produce painful symptoms at the level of the masticatory muscles,[ 27 , 28 ] but other studies find that the changes are not significant in relation to non-working side contacts.[ 29 , 30 ] This is due to resilience and tissue accommodation phenomena or contact wear due to increased mobility between teeth, which explains most cases with the absence of TMDs symptoms and in others, the presence of acute symptoms.
Although recent achievements have shown that results generated on blood samples collected from minor studies of screening for CRC by direct colonoscopy may have a certain value [ 33 , 34 ], there may be significant discrepancies between results generated in blood-samples from symptomatic patients and subjects undergoing colonoscopy screening [ 35 ].
The bond selectivity in DEA and the fact that the cross sections for this process may be significant at 0 eV electron incident energy opens up the attractive possibility to use this process to purposely enhance the cross-linking efficiency and explore the potential of site selectivity in the cross-linking step as a tool to control the properties, and ultimately, the functionality of the produced nanomembranes.
Conversely, the reverse reaction for off-target effects may be thermodynamically favored, but if the kinetics of dissociation are slow, then the off-target effects may be significant since there may be a long-residence time of the inhibitor and the off-target enzyme, which leads to no functional difference between reversible inhibition and irreversible inhibition on the time scale of cellular stress response.
Our finding suggests that the SNP rs12233179 in sex hormones regulation may be significant in Chinese female NSCLC, and provides new insight into the possible role of ovarian sex steroid hormones in lung cancer. 6 ETHICS APPROVAL AND CONSENT TO PARTICIPATE This study was approved by the Medical Ethics Committees of Human Studies at China Medical University, and written information consent was signed by each participant.