“may be significant”

An increased incidence of auto-immunity, exposure to pathogens both pre- and postnatally, and findings of antibodies to brain-specific antigens are common in disorders as diverse as anxiety, autism, depression, obsessive–compulsive disorder, schizophrenia, Parkinson’s disease (PD), and AD, together suggesting that differences in exposure and genetic vulnerability toward HM-mediated auto-immunity may be significant determinants of age-related neurological disease course and outcome as humans age ( 14 , 17 , 23 , 39 , 42 – 46 ); (6) secretory products of the GI-tract microbiome and translocation of these signaling molecules via the lymphatic and systemic circulation throughout the CNS are just beginning to be identified.

It has been reported that miRNA 148a and 30b may be significant indicators of early infancy fat accumulation and baby growth [ 197 ].

Late morbidity of re-irradiation in the base of the skull region may be significant, and a high level of clinical and radiotherapy planning expertise is required.

In this context, the high frequency of the RGD motif on an exposed loop in primate PSG N domains (seven of ten in human and five of fifteen in baboon) may be significant.

For medical staff, mastering Traditional Chinese Medicine(TCM) principles for health maintenance with food and diet therapy can provide patients with specific nutritional guidance and may be significant for medical practice.

False bifurcations have received relatively little attention in the dynamical systems community (a notable exception being the work of Marten et al., 2009 ), although our results indicate that they may be significant for understanding how ‘synchronisability’ of brain networks is reduced during seizures.

Our findings may be significant due to the potential for bezoars to cause intestinal obstruction.

If the reduction process of GO to RGO left defects in the graphene sheet, then the induced magnetism may be significant.

Therefore, the increased permeability of the choroid may be significant both before and after initiation of hemodialysis in the DM group from the effects of diabetic choroidopathy.

Caution is advised in recommending untested plant-based topical products for UA in women treated with AIs, as there may be significant, previously unrecognized, estrogenic constituents.

cruzi and human HGPRT with HPP (7-hydroxy-pyrazolo [4,3-D]pyrimidine, a compound similar to allopurinol) bound to the active site [ 11 , 13 ], subtle differences were observed in the binding that may be significant for novel compound design [ 13 ].

It may be hypothesised that in reaches where extensive and stable dam structures exist, the ability of beaver activity to act as a sediment sink may be significant.

Overall, these findings suggest that hub genes may play a critical role in cancer development and may be a useful marker for predicting the survival of cancer patients and may be significant in determining treatment outcomes.

Home rebound tonometry depends on patient adherence and is less suitable for nocturnal measurements, although it does not require surgical implantation; however, recurring costs for disposable components may be significant. 41 , 42 , 43 Contact lens–based sensors, such as the Sensimed Triggerfish (Sensimed SA), provide 24-hour recordings but are costly, limited to short-term use, and report IOP-related changes in arbitrary units rather than mmHg. 9 , 44 While the telemetric system used in this study was restricted to patient-initiated measurements, newer device iterations already enable automated and thus even more frequent data acquisition, for example, through wearable reader systems integrated into eyeglasses.

The first case had isolated pulmonary metastases, and this may be significant and partly explain his favorable outcome.

4 a, c) suggest that there is little to be gained by individualizing the treatment in Stage 2 since everyone benefits from the standard treatment, but at Stage 1 there may be significant clinical value in choosing treatment in a personalized fashion to maximize the overall DFS time.

A level with a p < .1 in ULR is usually chosen because a factor on this level may be significant in MLR.

Animal studies, using tract tracing, electrical stimulation, lesioning, and neural recording techniques were instrumental in identifying key subcortical regions important for bladder control, including the PMC which represents the major outflow tract to initiate micturition ( Loewy et al., 1979 ; Holstege et al., 1986 ; Blok and Holstege, 1997 ), the pontine continence center ( Holstege et al., 1986 ; Griffiths et al., 1990 ), the PAG, which receives afferent information about bladder filling and may be significant in switching from storage to voiding mode ( Noto et al., 1991 ; Blok et al., 1995 ; Liu et al., 2004 ), and the globus pallidus ( Lewin and Porter, 1965 ; Porter et al., 1971 ), amongst many others.

Although the impact of an acute disease may be significant, the functional trajectory can be independent of it ( 30 ) , with hospitalization playing a very significant role ( 15 ) .

Potential placebo effects in this study may be significant with an active device treatment.

The metabolites with RSD > 20 % in the original MCF-7 and MDA-MB-231 cell matrix QCs mostly appeared to be “low-abundant” or less sensitive metabolites with peak areas of 1000–30,000, for which matrix effects may be significant to interfere chromatographic separation and/or ionization efficiency.

Genes including CYP3A5, PDE8B, AOX1, BNIPL, FADS2, RRM2, ALDH3B2, and GSTM2 may be significant in the diagnosis and treatment of PCa.

There may be significant mechanistic diversity even between fish species.

The researchers conceded that there may be significant limitations to their analyses, as their conclusions were borne out of a meta-analysis of diverse commute-related datasets, and as a result, there may very easily be confounding factors–such as survey types/questions [26] , analysis units [27] – [28] , types of trips included [29] – [30] –in how the data are collected/analyzed that would have influenced the observed outcomes.

So there may be significant achievement in some states but not in Kano, where only 36 out of 1300 operate MSS.