“may be significant”

An emerging body of evidence now suggests that circadian rhythms, or natural 24-h cycles governing physiological processes, may be significant contributing factors to multimorbidity [ 7 , 8 ].

Combined detection of these indices may be significant in the evaluation of biological behavior and prognosis of BC and thus in the diagnosis and comprehensive treatment of this disease.

Conclusion We conclude that drug wastage and the ensuing financial loss may be significant during anesthetic management.

The reported auto-immune response to LL-37 in psoriasis may be significant in CAD given the increased risk of myocardial infarction in psoriasis patients [ 16 ].

Notably, the identification of OTUs belonging to Sphingomonas (OTU0054) and Lachnospiraceae (OTU0318) as differentially abundant between Dmbt1 −/− and Dmbt1 + / + and between precancer and OSCC diagnoses by both LSVCMM and fPCA analyses suggests that these OTUs may be significant for OSCC development and possibly regulated in some way by DMBT1.

There may be significant differences in underlying determinants of malnutrition in these contexts and populations, for which we lack standardised measures (UNICEF 2021 ).

In addition, the findings may be significant as a “roadmap” for clinicians working with children with autism and their parents.

Recent studies in mice suggested that there may be significant metabolism of fructose in the intestines.

na-t-SAH and aSAH-T may exhibit different bleeding patterns on CT, but there may be significant tentorial SAH in the former (Connolly et al., 2012 ; Perry et al., 2015 ).

The finding of seizure channels as a regulator of AKH secretion suggests that there may be significant parallels in the regulatory components of glucagon secretion and AKH cells.

This may be significant, as five of the six compounds are sub-micromolar inhibitors.

Thus, the findings may over‐represent access to diagnostics and antibiotic susceptibility testing capabilities, as there may be significant barriers to access off‐site testing capabilities. 6 Conclusion Reserve antibiotics can be introduced appropriately across LMICs using a phased and monitored approach, working closely with local experts and documenting best practices.

These preliminary findings suggest there may be significant gaps in the knowledge base surrounding CBF and IIH and a scoping review is the most appropriate way to search for the cause of these discrepancies [ 12 ].

Still, it would be of interest to evaluate whether features such as cANCA and/or pANCA, multiple organ involvement, response to treatment, and decades of presentation may be significant in increasing HM risk.

As a consequence, there may be significant differences related to the amount of energy involved in the injury that our material did not detect.

Such PAC drivers are expected to be complex but may be significant and fast acting mechanisms for population adaptation in a changing environment.

Immunotherapy has offered a second line of treatment; however, only approximately 20% of patients respond, and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to immunotherapy.

20 Accordingly, nonrestricted indoor contact and close proximity between sport team members may be significant factors aiding the spread of COVID-19.Furthermore, in badminton, a significant decline was noted in the athletes' levels of physical activity, with an increase in their idle time. 21 It is essential to point out that incidence rates can differ even within sports teams; young volleyball club players

There may be significant variation in the age of onset of the disease symptoms as well as the progression of symptoms even within the same family.

In the real tissue astrocyte swelling may be significant and may reduce flow of ions and oxygen (affecting Na + /K + -pump activity) contributing to seizures and spreading depression ( Hübel and Ullah, 2016 ).

Even if incomplete, the rescue afforded by reducing Fas activity may be significant to a patient suffering from one of these degenerations and further work should be conducted to explore this potential.

However, there may be significant limitations in the ability to diagnose labile gradients. 2 Reasons for limitations include poor acoustic windows, variability in the Valsalva maneuver, and contamination of the LVOT signal by the mitral regurgitation jet.

What's more, in the process of moxibustion treatment, there may be significant differences in the selection of acupoints and the frequency of intervention.

The impact of this triple mutation combination on hematocrit was less robust, but there is strong homeostatic pressure to maintain red cell production, so even a small variance in hematocrit may be significant.

Minor changes in sensor signals, typically dismissed as artifacts in adults, may be significant in neonates.