“may be significant”

The existence of such an optimization may be significant both for the entorhinal cortex itself (where a background θ rhythm is believed to play a role in the phase-coding of position information by grid cells [ 3 ]) and in other parts of the brain for which cell assemblies play an essential role in information processing, in that assemblies of intrinsically θ-frequency cells would be able to form much faster than assemblies of other cells.

Both these properties can be envisaged to play a role in the caries process and represent areas where strain differences may be significant with respect to pathogenicity.

ACKR3‐mediated scavenging of adrenomedullin (ADM) may be significant during heart and lymphatic vasculature development 233 .

Alternatively, a neuromarker may be significant and meaningful, but given cost constraints and resulting low power, not survive correction and result in Type II error.

Due to competition or cooperation, there may be significant relationships between pairs of hospitals, and between hospitals and pharmacies on a distance measure.

It may be significant in this respect that MdSWEET15a and EjSWEET15 appeared as likely candidate genes regulating sugar accumulation in apple and loquat, respectively 59 , 60 , as reviewed in 61 .

On the other hand, the PCA failed to identify Pb sources in Baihua Reservoir, but only showed its strong negative associations with F1, indicating that there may be significant sources other than F1 and F2 for Pb.

Nevertheless, pre-existing experiences and those occurring after birth may be significant in increasing women’s vulnerability to distress and maintaining the distress [ 32 ] and we cannot be certain that women’s responses were not influenced by prior events or those occurring at the time of survey completion.

( 2012 ) argues that, when comparing the US market with 22 emerging economies, there is integration in fluctuations in the long run, yet in the short run there may be significant differences.

Although smyhc1 stl583 homozygotes lack of F59 immunoreactivity, it may be significant that the F59 epitope is in an unmapped region of the myosin S1 head ( Crow and Stockdale, 1986 ) and could therefore be absent in a truncated protein.

In addition, exosome-derived miRNA may be significant in the metabolism, diagnosis, and treatment of cancer.

The challenge with assessing COVID-19 severity is that asymptomatic hypoxia often precedes breathlessness, and by the time symptoms of breathlessness occur, patients have developed advanced disease and hypoxia may be significant. 4 The ability to detect this asymptomatic hypoxia before patients experience shortness of breath is critical for preventing respiratory involvement from progressing to a life-threatening state.

These five factors may be significant predictors of the development of metachronous metastasis.

Abstract Objectives: Growing evidence suggests that there may be significant long term sequellae of cumulative concussions, which may include prolonged cognitive deficits and physical symptoms.

Biomedical implications of immunoproteasome activators may be significant to overcome deficiencies in immunoproteasome activity as seen in proteasome-associated autoinflammatory syndromes, as well as modulate antitumor immune responses, autoimmune and neurodegenerative diseases, and aging.

It may be significant that many previous studies have used malignant cells whereas we are using transformed HEK 293 T cells, which are not derived from a primary cancer.

Invasive species like rainbow trout ( Oncorhynchus mykiss (Walbaum, 1972)) and red swamp crayfish ( Procambarus clarkii (Girard, 1852)) may be significant threats to Megaloptera populations, either by competing with or preying on hellgrammites.

These findings imply that various biomarkers may be significant for de‐escalation, and one should not solely depend on having a small tumor volume and being a never‐smoker, as is currently being done [ 24 , 35 , 54 ].

Although crypts may be significant findings in a familial context with a high pretest probability of HCM, their clinical significance is doubtful when isolated findings in asymptomatic patients, probably representing, in these cases, only incidental variants of local myocardial structure.[ 24 29 30 31 ] According to Erol et al .,[ 1 ] we believe that all these fissure-like lesions, sometimes called recesses, crypts or clefts are the same entity and maybe only the term crypts should be used to avoid confounding terminology but, again, an agreement is warranted.

Again, it may be significant of serious constitutional disease, especially if met with in infancy and associated with snuffling and skin eruptions.

As with other infrequent outcomes, a relationship may be significant in future studies directly measuring individual VitD status – serum 25(OH)D concentration – instead of a proxy measurement.

Similarly, even in healthy humans, there are some cilia with structural abnormalities ( 72 ), which means that the influence on synchronization of nonidentical cilia may be significant.

Bone mineralization and age-based bone growth can be checked and related to levels of GH/IGF-1.[ 3 ] GH deficiency affects body composition, physical performance and substrate metabolism and its replacement attenuates these effects; short-term and long-term effects of replacement may be significant.[ 4 ] It is important to remember the physiological effects of deficiency of the hormones in the peri-operative period.

Furthermore, there may be significant bias in terms of the age and sex of people who are willing to discuss and share their health-related experiences online.

Our findings are consistent with a growing body of evidence that there may be significant heterogeneity in the association between acculturation, health behaviors, and chronic disease prevalence.