Barely Significant
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“may be significant”

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In the literature

62 , 63 Regulation of AP-1 pathways by RSG may be significant, as AP-1 has been shown to be involved in both angiogenesis and inflammatory signaling in the retina. 64 Syndecans are a small family of membrane receptors known to interact with actin cytoskeleton, ECM, GF, intracellular kinases, and integrins to regulate cell survival, proliferation, adhesion, an
In the specific case of articular surface impaction injuries, acute contusion of the cartilage may or may not be associated with clinically detectable articular surface fracture even though there may be significant cell death. 50 As regards habitual articulation abnormalities responsible for gradual onset of progressive tissue damage and degradation after joint trauma, 2 common manifestations are joint instability and residual articular incongruity, both of which involve well-documented levels of chronic local contact stress elevation. 9 , 51 - 53 Acute high-intensity joint injuries that initiate joint degeneration involve damage of the articular surface.
In this context, the As load removed within a short period may be significant especially in adjacent areas of mining activities, although as previously referred [ 18 ], the leaves of Eucalyptus camaldulensis and Eucalyptus globulus growing in heavily contaminated soils around a deactivated mine exhibited foliar As concentrations up to 0.6 μg g −1 , a level sixfold lower our minimum value, thus indicating that “ all the extrapolations from plant behavior in vitro must be avoided or done with great care ” [ 65 ].
When considering direct transmission of viral pathogens from mother to offspring, it is essential to understand that the pathological consequences may be significant despite preexisting maternal seroimmunity, as demonstrated by the relevant congenital morbidity, and mortality observed after secondary infections with other viruses, such as CMV and pestivirus. 17 , 18 Furthermore, in our previous studies performed in rodent models, all RSV‐infected dams developed