“may be significant”

However, in the case of proteins with unique topologies, as seen in knotted proteins [23] , [24] , [28] , the effect of the excluded volume may be significant as the internal radius of the slipknot is reduced and can impact the threading event.

Past medical history may be significant in the occurrence of KMs which may imply that they are a manifestation of diseases rather than independent entities occurring in otherwise healthy individuals.

Still, the forecast product losses may be significant as this membrane presents a rejection to MEL of only 87.1%.

However, if the recombination stretches over large fractions of the genome, it may be significant.

Aiming to address whether such extensive hydrocarbon gas venting may be significant in the context of global marine methane seepage, we compare our gas flare mapping results with other pronounced marine seep regions that have been surveyed with echosounder systems.

However, losses of tau in the drainage pathways may be significant.

In this context, the capacity of the FIB-4 score to predict the risk of sarcopenia, is not limited to patients with liver disease, but may be significant for the general older adult population.

The CFR may be significant among these infections, such as 18% for WNV encephalitis 29 and 20% for JE. 30 The CFR following TBE depends on the viral subtype: the Far East subtype is known to be more pathogenic than the Siberian and European subtypes, with the CFR following TBE due to the European subtype reportedly being less than 1%. 31 Flaviviruses share a common neurotropism for the thalamus, basal ganglia, brainstem, and anterior horn cells of the spinal cord. 32 , 33 Their clinical presentation and outcomes consequently share common features and sequelae, although there also are some differences.

It can be seen that there may be significant differences between MP and MC in gene expression.

There may be significant differences when looking at these subgroups, which can help to guide treatment options.

Interestingly, the two miRNAs common to all the three treatment groups were all differentially expressed in the same direction, indicating that these miRNAs may be significant in some of the changes associated with protection against pathology.

For EPHB4 binding, interactions with Ile15, Ala39, Leu141, and Asp152 may be significant for GK03499 and GK03503.

Second, that organisational barriers (opportunity) may be significant even when individual motivation and capability are targeted.

It is possible, therefore, that with more repetitions and/or additional sets of exercise there may be significant and divergent relationships for average submaximal concentric torque across LLBFR and LL conditions.

As mentioned in the Introduction, recent reports from practice clearly indicate that shared leadership may be significant for achieving project success, yet they do so without providing any scientific justification.

This may be significant because OPG208 is a member of a set of genes most likely responsible for increased virulence of clade I MPXV compared to classical (pre-epidemic) subclade IIa MPXV 40 .

In any event, these findings in human suggest that there may be significant differences in MGE and LGE across species, and that at a minimum ERBB4 expression and function are not conserved across species.

It is suggested that there may be significant differences in the onset of the disease, the knowledge of which could help us to understand and prevent its behavior based on geographical area.

For instance, there may be significant variations with respect to design, sample size and patient selection which cannot be incorporated by our network meta-analysis.

This bias toward alternative isoforms with subtle changes in protein structure and function is a strong indication that there may be significant selective constraints on the translation of protein isoform.

The rationale for this is that preoperative periorbital swelling may be significant enough to occlude vision in one eye or hinder double vision temporarily.

While PD-L1 expression has not completely correlated with therapeutic activity to checkpoint blockade in melanoma, this may be significant when considering other cancers where PD-L1 expression may be important for clinical activity with checkpoint blockade.

immitis may be significant and these variations are detectable in biochemical assays of metabolism and ABC transporter mediated efflux.

The capacity to load adjuvant-particles like AFCo2 or AFCo1 by simple admixing with antigen may be significant in epidemic settings where speed of vaccine manufacture is critical to minimize resultant mortality and/or morbidity [8] .

While we do not have district-level information about hourly diurnal cycles of fire activities due to a lack of comprehensive in-field studies, our broad conclusion is that there may be significant benefits yielded by encouraging fires to be set earlier (10:00–13:00 LT) in the day rather than later (14:00–17:00 LT).