“may be significant”

Although OMAS and WHO both appear to be valid, literature reviews have highlighted that the subjective WHO and objective OMAS are delivering different knowledge and it may be significant for future clinical studies to include both scales together.

The increase in fatty acid ingestion may be significant, since fatty acids (particularly n-6) can promote differentiation of preadipocytes into mature adipocytes [69] , which express leptin [20] .

The subjective reference effect may be significant if the two terms have opposite signs, but such cases rarely occur within a short time interval.

An important aspect to bear in mind is those target proteins identified as essential may be significant for bacterial survival only under laboratory conditions and not in the infection process ( Zuniga et al., 2015 ).

While likely not a function exclusively of organizational or hospital-level factors, these data do not preclude that there may be significant individual- or team-level practice variability.

Although the precise mechanism explaining the cytotoxic response of rsEpiSCs to cholesterol remains unclear, there may be significant differences in cholesterol metabolism between naïve and primed pluripotent states in mice, which could influence cell survival and proliferation.

These findings collectively suggest that targeting non-coding RNA, including miRNA and lncRNA, may be significant for advancing RNA-based therapies in treating MDR-TB.

In particular, this study addresses the reaction kinetics between BPA and 3 4-CB* under conditions that may be significant for surface freshwaters, sea-water surface, and marine aerosols.

Reversal of the RofA three SNPs in M1 UK As the RofA regulon in M1 UK appeared distinct from M1 global , it seemed possible that the three SNPs present in rofA in the M1 UK lineage may be significant in this strain background, noting that the strain background is characterized by a number of additional SNPs that may alter strain physiology.

These two issues may be reasonably accepted in healthy subjects, whereas they may be significant confounding factors in CKD patients.

Secondly, disease modification trials typically have long durations (years) and there may be significant competition for eligible patients carrying a specific genotype.

From studies without incentives, we know that age and gender may be significant predictors of PA program adherence.

A Longitudinal study may be significant to determine whether this method can effectively assess the progression and amelioration of T2DM over time.

Gingival telangiectases may be significant in identifying subsets of dermatomyositis. 1 Capillary abnormalities in the gingiva have been previously described in five patients with dermatomyositis 2 , the mechanism of which is speculated to be similar to that of periungual erythema. 1 , 2 , 3 There is also one previous report of a patient with multiple oral lesions, including gingivitis, as the initial symptom of dermatomyositis. 3 Thus, gingival telangiectases may represent the sign of dermatomyositis.

We also found that genes with potentially functional mutations ranked significantly less intolerant to rare variation, complementing recently proposed hypotheses that DNMs may be significant risk factors for sporadic schizophrenia 16 , 47 .

24 Even if a patient’s dyskinetic movements are considered mild, the impact of TD may be significant to that individual. 24 Other elements to consider when pursuing TD treatment include the individual’s risk for worsening TD and the impact of treatment on the underlying psychiatric illness. 10 , 11 Treatment of TD is appropriate when the impact of TD outweighs the risk of treatment. 7 Examples of factors that may worsen TD and TD impact include antipsychotic medication, anticholinergic medication, and external circumstances/stressors (eg, the current global pandemic). 47 Discussion TD can have a profound negative impact on many different functional domains.

The positive effects of social participation on health may be significant for elders because elders have more times to take part in social activities due to retirement or fewer familial constraints [ 26 , 27 ].

Significantly, bacteria forming opaque rings demonstrated enhanced levels of exopolysaccharide (EPS) production and elevated stress resistance indicating a significant physiological adaptation which may be significant in different phases of the infectious cycle (Tiensuu et al., 2013 ).

On the other hand, in esophageal invasive carcinoma, there may be significant heterogeneity within the cancerous tissue, leading to aberrant and disorganized keratinization and the formation of so-called cancer pearls [ 36 ].

Thus, macronutrient composition and relatively high glycemic index may be significant factors contributing to increased adiposity and glucose intolerance in our HED pigs.

Thus, the impact of the pandemic on registered clinical trials investigating depressive disorder interventions may be significant and warrants investigation.

This suggests that there may be significant differences in the force balance between podosomes and phagocytic teeth.

Computed tomography pulmonary angiogram has an overall good inter-observer agreement in diagnosis of large and central pulmonary embolism, but there may be significant discordance among radiologists particularly in evaluation of solitary, segmental, and small pulmonary embolism.

There may be significant logistical barriers or lack of resources for these schools that should be considered.

There may be significant differences between 2 groups at long term follow-up, such as 1 year or 2 year.