Barely Significant
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“may be significant”

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In the literature

UNESCO ( 2020 ) advocates that “Investment in remote learning should both mitigate the immediate disruption caused by COVID-19 and establish approaches to develop more open and flexible education systems for the future”, and while the short-term challenges may be significant, the COVID-19 pandemic may stimulate advances in remote delivery in the longer term.
Such small differences may not be clinically significant when considering contour propagation, but may be significant when reviewing dose accumulation, especially in high‐dose gradient regions. 16 A surprising finding was that, on average, the differences in TRE between institutions using the same software were not statistically significant when accounting for the change in MIM versions as shown in Tables 4 , 5 , 6 .
11 Analyses both within and outside of the GWTG-HF program have highlighted that out-of-pocket cost, prior authorization requirements, and formulary access issues associated with SGLT2i and ARNI may be significant barriers to use, compared with therapies with generic pricing available. 12 , 13 Applying Clinical Trial Findings to Real-World Populations While clinical trials have demonstrated substantial benefits with evidence-based therapies for management of HF, it is critical to understand how these benefits apply to the general population.
These data confirm that there may be significant benefit in combining Nutlin-3a, cytarabine, and miR-10a inhibition in miR-10a-overexpressing AML cells, potentially allowing increased efficacy and/or decreased dosage and therefore toxicity while maintaining equivalent anti-leukemic activity. miR-10a regulates the p53-mediated switch between autophagy and apoptosis Activation of the p53/Rb-mediated stress response is potentiated by increased expression of miR-10a target RBCC1 via its direct binding to and stabilization of p53, and subsequent upregulation of Rb, p16, and p21 [ 25 ].
However, there are numerous other industries where beryllium exposure may be significant ( 56 ), and more cases of CBD have found to have been misdiagnosed sarcoidosis cases when a detailed occupational history for beryllium exposure has been elicited ( 55 ).
Granulomatous Sarcoidosis Mimics.
Front Med (Lausanne) · 2021 · PMC8295651