Barely Significant
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“may be significant”

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In the literature

Such flow in normal brains is not significant compared to that from high flow rate infusions, but it may be significant in either chronic infusions or, more pertinently, in brains with pathological states of disrupted blood–brain barrier (BBB), where there are endogenous sources of fluid as well as serum proteins from the vasculature that alter the oncotic pressure in the interstitium [ 43 ].
The duration of CaMKIV manipulation may be significant, as in vitro experiments have generally used either short pharmacological manipulations or brief genetic manipulations lasting only 24 h or so ( Pratt et al., 2011 ; Joseph and Turrigiano, 2017 ) while our approach (conditional knock-down or viral expression in vivo ) limited us to examining the impact of longer manipulations.
In cases where the symptoms are moderate to severe, there may be significant morbidity and impairment of the nutritional and volume status, which may necessitate hospitalization and affect the patient’s eligibility to receive further cancer treatment. 20 The use of ICIs (CTLA-4 and PD-1 inhibitors) was linked to a higher risk of both all-grade and high-grade colitis, according to a previously published meta-analysis.