“may be significant”

In rare cases, there may be significant off‐label usage, but the reasoning behind this off‐label usage should be carefully considered in terms of its impacts on patient selection. 71 , 72 Significant differences between the patients receiving the off‐label treatment vs. the existing standard of care could exist, resulting in issues of generalizability.

The inertial term in the case of open topology may be significant under extreme conditions (see Text S3 in Supporting Information S1 ), and the amount and accuracy of LPW data would affect the results especially in the open topology case (see Text S4 in Supporting Information S1 ).

Finally, this study did not include age, gender, or other factors, that may be significant.

The mirrored pattern of human and Mtb phylogeography indicates that co-evolution has likely occurred, and consequently, that genome-by-genome interactions may be significant.

In this study, the number of identified missed injuries may not be statistically significant between the two teams in each group, however, it can be postulated that the identified missed musculoskeletal injuries by the physiotherapists may be significant to the individual patients with the new “missed” injury such as a hand injury.

However, the results of meta-regression and subgroup analyses suggest that such differences may be significant in subgroups of patients with schizophrenia, particularly older patients with relatively low HDL–cholesterol concentrations.

Moreover, there may be significant disconnect between patient and physician perceptions surrounding this decision, as has been reported for other aspects of RA management, such as patient versus physician priorities for symptom improvement 18 and assessment of disease severity. 16 As such, there may be unique value in determining the patient perspective.

Considering that loss of NR2F6 enhances antitumor responses in T cells, especially during immune-checkpoint inhibition [ 29 , 30 ], loss of NR2F6 in NK cells may be significant for tumors that lack potent T cell epitopes or have downregulated MHC-I expression as an escape mechanism, offering a potential avenue for a combinatorial therapeutic intervention.

Although two studies on lymphatic leakage after NB surgery define major abdominal drainage (greater than 300 ml/day and 400 ml/day) as lymphatic leakage [ 8 , 10 ], there may be significant differences in the amount of drainage among children with different body weight.

technical, human resources) which may be significant higher in public hospitals [ 20 , 30 ].

Therefore, the non-immune-dependent functions of nuclear PD-L1, such as participating in tumor pro-inflammatory pathways and reprogramming the expression of genes related to immune responses, may be significant for immunotherapy (Fig. 5 ).

Although we are aware of the many differences between healthcare and aviation, and appreciate that these may limit a direct transfer, it may be significant to mention that aviation served as a reference in establishing safety practices in healthcare, at least in the initial stages [ 11 ].

Two phases of allergic response may be significant.

DNA methylation primarily occurs at cytosine residues within CpG dinucleotides, although it is becoming increasingly evident that there may be significant methylation in non-CpG (CpH) contexts, at least in pluripotent cell-types and oocytes [ 6 – 8 ].

These may be significant influencing factors [ 9 , 23 ] and may help to identify vulnerable groups at an earlier stage.

Despite updated guidelines, there may be significant variations in diagnosis and management of chronic obstructive pulmonary disease at a primary care level.

This finding and the difference between the two PARPi may be significant considering the poor results of clinical trials with PARPi including Cisplatin‐pretreated patients.

Whilst ducks and geese may be significant reservoirs of AI viruses, including highly pathogenic variants, the performance of vaccines in these species is largely unknown.

It may be significant that the increase in prevalence of ATM has been coincidental with the increase in prevalence of AHPND outbreaks.

This window of vulnerability may be significant as it could facilitate early seeding of virus and its local expansion within a small founder virus population. 50 Such virus populations might be controlled during periods of therapeutic drug concentrations but could self-propagate when CAB and RPV are below inhibitory concentrations. 51 However, a pharmacological lag does not appear to be a viable explanation for the failures we observed in this study.

The antioxidative effect of TFPN may be significant in the mechanism by which they prevent arterial inflammation and endothelial dysfunction.

In addition, the protective efficacy of ribosome-based vaccine formulations is controversial since many include surface protein contaminations, which may be significant contributors to the protective responses ( Pregliasco et al., 2009 ).

[17] also obtained a positive mean difference value (2.55) but with a significantly higher value, which may be significant for basophils, which are, in general, presented in a lower percentage in peripheral blood.

Despite the low level of mutations among the orthologous receptor sequences used as the current input data, the high sensitivity and specificity obtained in our results may be significant for prediction results produced by the statistical model based on evolutionary and genetic similarities between potential host species.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.