Barely Significant
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“may be significant”

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Conversely, in the low antigen presentation myeloid niche, myeloid markers including TLR2, CLEC4A, and CSF1R are spatially co-expressed with T cell markers IL7R, TCF7, FYN, and TNFSF14, indicating there may be significant interfacing between myeloid cells and T cells in this niche ( online supplemental figure 4B ).
An orthotopic model of skin SCC showed the lack of expansion of cancer-associated fibroblasts (CAFs) due to NOTCH1 gene silencing, without affecting the integrity of normal fibroblasts, and this may be significant for patients with a higher risk of skin carcinomas because of immune-suppressive therapies [ 37 ].
Last but not least, the opportunity of modulating the surface architecture of the zein nanoparticles through the linkage or deposition of targeting moieties and the co-encapsulation of other active compounds within the protein matrix may be significant technological advancements able to improve the safety and the effectiveness of the formulation for the treatment of OC.
This study's hypotheses are as follows: (1) The neglect group may utilize the adaptive strategy (reappraisal) less frequently and have more depressive symptoms; (2) There may be significant differences in prefrontal functional connections with other brain regions between the two groups; and (3) The prefrontal functional connections with other brain regions may be significantly correlated with the scores of emotion regulation strategies and depressive symptoms, and emotion regulation strategies may mediate the relationship between the above functional connections and depressive symptoms. 2.