“may be significant”

It is appreciated that there may be significant differences in clinical outcomes comparing how a drug performs in a well-controlled trial compared to how a drug performs in routine clinical practice, i.e., in the “real-world.” An NDA data package compile comprehensive, well controlled, data essential for the FDA and other regulatory review bodies to assess authorization for marketing; yet it may be incomplete for other key stakeholders, such as 3 rd party payers and some needs of patients and prescribers.

It may be significant that two out of the eight genes found to have a Fur box, iroN and ybtA , were acquired by lateral gene transfer from other pathogens ( S. enterica and Yersinia pestis , respectively) ( 56 , 57 ).

The findings of this systematic review that factors leading to non‐terrorist crimes may be significant predictors of radicalisation and violence seems to suggest that some policing strategies such as community policing, supported by appropriate risk assessments, may be capable of effective deployment to prevent these crimes too. 5 FAMILY FACTORS FOR RADICALISATION Whilst Sarma et al.

The various characteristics of our deceased patients, including demographics, clinical manifestations, laboratory and radiological parameters, may be significant predictors of poorer outcome in COVID-19, but at the same time, this needs further evaluation and analysis on a wider scale to stratify the risk and understand the exact mechanism behind the enormous mortality.

These individuals may be significant to mothers who are not employed or depend entirely on others for survival and decision-making [ 17 ].

4 (2B)), tank saturation time (B) on the retention factor of the drug may be significant.

These results may not apply to other populations as there may be significant differences in subjects’ characteristics and healthcare dynamics as the larger proportions of subjects in this study were young, male, expatriates living in relatively higher proportions of shared living.

In degenerative cartilage diseases such as osteoarthritis, degradation of the proteoglycans has been shown to precede breakdown of the collagenous molecules [ 23 ], so a greater initial upregulation of stromelysins may be significant in this regard.

There may be significant differences in glycogen degradation, intercellular storage and VFA metabolism among different kinds of GAOs (McIlroy et al. 2014 ; Oehmen et al. 2006 ).

Strikingly, the deficiencies of the double-activating signals may be significant with respect to NK-cell tolerance.

In addition, being a multicenter study, the heterogeneity of practices could not be fully accounted for in the statistical analysis even though they may be significant.

This may be significant because RutR is known to negatively regulate transcription of the rut operon in E. coli (involved in pyrimidine utilization) [ 41 ].

Nevertheless, there are some variations in cell lineage that may be significant in the development of natural diseases.

and Øberg et al., having an active role in predictive assessments and early intervention may be significant for the parents’ relationship with their infant, and building knowledge together with skilled professionals can reduce parents’ fear [ 37 , 38 ].

As little as 60 ml of blood within the pericardium can produce clinical tamponade, and bleeding from myocardial injuries may be significant enough to cause coronary artery hypoperfusion and cardiac ischemia [ 4 ].

Most of our knowledge lies in the downstream effects of epigenetics, and a deeper understanding of the causes and factors that undermine epigenetic alterations may be significant in explaining the differences between the healthy and diseased states.

We imagine that our approach could also be used to detect the impact of particular genetic mutations, given earlier work suggesting that there may be significant differences in network activity [ 24 ].

Although necrotic tissues are also present on the surface of shallow deep second-degree burn wounds, the tissues are thinner, unlike those of profound deep second-degree burn wounds; using good dressing coverage may be significant for preventing the transformation of interstitial ecological tissues.

Human subject usage will not happen in the near future but will keep generations of researchers busy as potential benefits may be significant.

For example, chironomids can fertilize soils adjacent to lakes when they emerge as adults (an estimated potential local load of 0.5 kg N per hectare per year N and 0.05 kg P per hectare per year N), and water birds such as geese and ducks may be significant vectors (van der Wal et al., 2007 ).

Taken together, these results from our analysis of FHS data support the hypothesis that the genes B4GALNT2, AKAP7 and DYRK1A may be significant for development of CVD although further molecular tests are needed to test these hypotheses although further molecular tests are warranted.

The findings may be significant in developing better intervention strategies for infantile esotropia.

Subtle differences in plant stature and leaf number may be more meaningful when a plant grows with neighbors of the same and other species [ 49 ], so that responses among individuals may be significant for those individuals even if the average response seen in isolated plants may not be.

There may be significant differences in efficacy and survival impact between patients due to factors such as age, gender, genetic background, tumor stage, and treatment history.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.