“may be significant”

The reactivation of HCMV in immunocompetent individuals typically results in no or mild symptoms, though it may be significant in some cases, and reactivation can be severe in the immunocompromised [ 9 ].

Additionally, the entire examination protocol was performed by a single experienced operator in a single center, which enhances internal consistency but limits extrapolation to other settings where inter-operator variability may be significant.

The components of the HRQOL may represent independent predictors of survival and may be beneficial when used clinically to make treatment decisions.[ 7 ] Several studies in the literature on PBT have focused on the role of specific facets that may serve as significant prognostic factors of survival such as gender, cognitive and social functioning, depression, tumor location, and histological classification.[ 16 19 33 36 ] We have designed a study to attempt to determine which items of the EORTC QOL measures may be significant predictors of tumor progression on magnetic resonance imaging (MRI).

Given the unregulated nature of melatonin, there may be significant variation of bioavailability depending on the source of the exogenous melatonin and the metabolic rate of the patient of which it is administered [ 6 ].

The benefit may be significant from a scientific production point of view, but it can also have a crucial social role for public opinion of science and CS.

As these may be significant factors when selecting suitable individuals for future treatment.

During the transition of the PRS states, there may be significant transient currents in practical application scenarios, which need to be further considered when constructing the microgrid for specific applications.

The financial and social consequences of such errors may be significant [ 1 ].

Furthermore, the absence of any immune response in our mouse model may be significant.

However, while the evidence that restricting maternal diet during pregnancy and lactation helps to prevent allergy is weak, the risks of maternal undernutrition and potential harm to the infant from avoiding these foods may be significant.

2D ), indicating that miR-708 and miR-31 may be significant in CRC development.

This may be significant in the context of a recent study comparing “unrestricted” built environments (public houses, public buildings, private houses) with “confined” built environments (intensive care units (ICU), cleanrooms, cleanroom gowning areas) where it was shown that each of the three “confined” environments had a considerably higher representation of amino acid utilization compared to carbohydrate utilization, with the opposite being true for the “unrestricted” environments (higher carbohydrate utilization compared to amino acids) [ 50 ].

While the improvement was modest and may not be considered clinically important at an individual level, it may be significant at a population level [ 46 ].

The high frequency of TAMs and ratio of Treg/Th17 cells in late tumor grades suggested that they may be significant in tumor progression.

This relatively simple approach to alleviating anxiety may be significant as there are well established theories propounded over fifty years ago linking raised levels of anxiety and fear during pregnancy with increased levels of pain during labour [ 21 ].

Given the lack of differences identified in the remaining ACSI measures, additional work is needed to further investigate the relationship between athletic identity, coping mechanisms, and fear avoidance as it may be significant to injury outcomes ( Fischerauer et al., 2018 ).

Together they indicate a later period of use for birch bark tar in the UK than has been previously observed and raise the question of whether this indicates evidence of a longer continuity of use than hitherto recognised or a later reintroduction of the technology in the Medieval period, in which case the similarities between the find sites, both early Anglo-Saxon cemeteries with comparable assemblages of grave goods, may be significant.

The occurrence of physical or sexual aggression of caregivers by patients in the advanced stages of the disease is rarely investigated during consultations, but may be significant, adding to the overall burden (Bruno et al. 2016 ).

The medical impact of the finding, that about 50% of the drugs tested here are substrates of the H + OC antiporter, may be significant.

Finally, our results suggest that beta cell dedifferentiation and neogenesis of pancreatic cell lineages occur simultaneously, most likely directed toward non-beta cell types, which may be significant for the development of therapies or dietary interventions aimed at prevention or targeted differentiation toward the desired pancreatic cell lineage.

In this respect, it may be significant that NSN-to-SN transition, i.e., karyosphere formation, is accompanied by a change in the specific pattern of epigenetic markers (modified histones) in mouse [ 17 ], porcine [ 18 ], and human oocytes [ 19 ].

Moving to GLP1-RA, another class with proven cardiorenal benefits used solely in patients with type 2 diabetes mellitus, we should state that there may be significant within class variations regarding efficacy, weight loss, and tolerability [ 151 ].

Overall, findings suggest that the type and quality of each faculty practice or measure of interaction with students may be significant in terms of fostering positive diversity attitudes among students.

Clinically, identification of a basal variant may be significant, since basal tumors are associated with more aggressive behavior and better response to chemotherapy.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.