“may be significant”

This finding suggests that despite patients in this category receiving significant support in the area of spiritual and psychological care, there may be significant gaps in classic structural administrative support for palliative care services.

The regulation of miRNA-196b by DNA methylation has been shown to be involved in the development of many other cancers and may be significant in CML.

In such an environment, cardiologists may be significant professionals.

Each mutation may be significant for an individual patient.

Considered in isolation, this result may suggest that it would be more the (ir)regularity of time series variability than the level of complexity with respect to scale invariance which may be significant in terms of adaptive capacities.

Nonetheless, a modest impact on TNFα production may be significant, as positive feedback loops leading to enhanced TNFα production might amplify the impact of this SNP in vivo [33] .

One of the consequences of autophagy impairment may be significant accumulation of a toxic drusen component (amyloid β fragment, Aβ 1–42 ) in the aged retina of OXYS rats [ 17 , 18 ].

These shifts may be significant ( e.g. , there is a “blue shift” of 1 eV in the lowest excited state of water between the gas and ice phases) and may lead to quenching of some electronic states ( e.g. , Rydberg states), which can significantly change the excitation and dissociation of molecular species in different phases influencing the local chemistry. 442 Limitations and Challenges : EELS requires the samples to be placed within a high vacuum (typically <10 –5 Torr).

Lastly, for therapies that have been approved for other indications and there is off-label commercial access, there may be significant off-study use with patients and treating physicians being reluctant to participate in a randomized controlled trial.

These results suggest that central obesity or low muscle mass, combined with low basal metabolic rate, may be significant risk factors for increased CI in middle-aged and older patients with T2DM.

Conclusions and Future Directions Many inflammatory cytokines and chemokines are involved in atherosclerosis where targeting one specific mediator might not be effective as the rest of the cytokines level might not be targeted and its effects in triggering the inflammatory response may be significant.

It was shown that CCR7 expression was positively correlated with lymph node metastasis, tumour size, and clinical stage, and these authors postulated that the interaction between this chemokine and its receptor may be significant for the induction of lymphatic spread.

As the tumor is highly vascular, there may be significant intraoperative blood loss which may influence the hemodynamic instability and necessitate blood transfusion.

Preliminary analysis suggests that socioeconomic status, geographical location, and preexisting health conditions may be significant risk factors for unmet health care and dental care needs, highlighting the complexity of the issue [ 6 , 7 ].

Given the potential of GPR146 as an immune modulatory molecule, its involvement in regulating inflammatory and immune responses may be significant.

DELLA proteins may be significant in these interactions, where at least some ethylene response factors have been shown to interact with DELLA ( Marín-de la Rosa et al., 2014 ).

The difference between the patient's skin and ambient temperature during the interval from entering the operating room through anaesthesia induction until draping and active warming may be significant.

AKT1, TNF, VEGFA, STAT3, CXCL8, PTGS2, TP53, and CASP3 may be significant targets of Tripterygium wilfordii in the treatment of OLP, according to the analyses using STRING and CytoNCA.

These results showed that the economic impacts on the Maine wild blueberry industry may be significant if infestations were left uncontrolled or if growers attempt to avoid crop value loss by using insecticides.

This may be significant as recent data indicate that cell motion may be an intrinsic feature of hESCs ( Li et al., 2010 ).

While contentious, the consequences of this may be significant, particularly where the communities fail to recover over an extended period, as observed here.

However, its content in infant formulas has recently come to light, and analysis has shown that intake during the first year of life may be significant ( Table 2 ).

118 This suggests there may be significant inter‐individual variation in the response to certain dietary interventions, which are driven by underlying genetics, and this should be leveraged to design more personalized interventions.

This suggests that pulmonary vascular dilatations (or intrapulmonary arterial–venous anastomoses) are not a major mechanism of hypoxemia in classical ARDS but may be significant contributors to hypoxemia in COVID-19 respiratory failure.

These results may have implications for understanding how glaucoma patients are affected in daily tasks where crowding effects may be significant. glaucoma visual crowding visual function pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-p