“may be significant”

[ 163 ], examining 2570 elderly individuals (mean age, 73.1 ± 10.4 years) over a 6 year period found that the methionine to Hcy status was associated with dementia development and structural brain changes, suggesting that a higher methionine to Hcy ratio may be significant in decreasing the rate of brain atrophy and decreasing the risk of dementia in older adults.

Radiation may be significant in treating immunologically ‘cold’ tumors that usually do not have an adequate response to immunotherapy ( 3 , 4 ).

Indeed, our results suggest that (i) MG II may be significant contributors of 2G-GDGTs ( Figure 3 and Table 1 ) and (ii) 2G-GDGT cyclization degree is only weakly impacted by temperature.

This observation may be significant in the context of Rac1-mediated beta-cell dysfunction under these conditions in that we have recently demonstrated a significant degree of association of Rac1 with the nuclear fraction (mislocalization or mistargeting) in INS-1 832/13 cells, normal rat islets and human islets exposed to glucotoxic conditions [ 24 ].

Nevertheless, it is possible that the effect of individual drugs on the mycobiota may be significant and requires future investigation.

This most likely has only a minor influence on the outlet composition; however, in the region of the feedstock inlet port, it may be significant.

The longevity of some EMIC wave events coupled with their anticipated presence over many hours in MLT, near the plasmaspheric boundary where conditions for their excitation prevail, suggest that EMIC waves may be significant contributors to outer belt electron losses during active times.

[1 , 7 , 8] This decrease may be significant, as low CRS is independently associated with mortality in patients with ARDS whether treated with ECMO or not.

In a direct comparison between suture-induced and alkali burn-induced corneal inflammation, alkali burn produced a less pronounced lymphangiogenic response but a similar hemangiogenic response, indicating that differences in the method of induction of inflammation may be significant for corneal lymphangiogenesis [ 208 ].

Moreover, the included studies were from different countries, and due to national policies and ethnic differences, there may be significant differences among these studies.

demonstrated that a mutation in the CLOCK gene induced endothelial dysfunction was associated with the attenuation of Akt signaling and a subsequent decrease in nitric oxide production that may be significant in the progression of vascular diseases [ 51 ].

The maternal genes in this genomic region may play a role in a dose‐dependent manner, and the copy number of these genes may be significant in terms of brain development.

Evidence points in different directions, and it is essential to note that there may be significant variations in the types of videos used in these studies.

The increase in activity may be significant, considering the functional representations in the medial frontal cortex.

This study may be significant in improving occupational health services for work-related cancer prevention.

However, this widespread use does not escape criticism, principally due to issues such as difficulties in classification of paralogous versus orthologous rDNA units and intragenomic variation, both of which may be significant barriers to accurate phylogenetic inference.

The CD8+ decrease may be significant in patients with death outcome in comparison with those who recovered.

It is possible that age-related variables, as well as differing blood alcohol concentrations, may be significant contributing factors to the differential findings in ceramide profiles, as the acute ethanol doses administered by injection [ 21 ] or intubation [ 22 ] in the former studies would be expected to result in higher BACs (particularly in neonatal rodents) than those previously reported via voluntary drinking by adult P rats in the intermittent access paradigm (11–63 mg% [ 27 ]).

In most practical situations, the volumes of the donor and acceptor compartments are different, and the volume of the membrane may be significant, leading to different predictions of the permeability coefficient when following all the solute or only that in the aqueous compartments, Figure 11 .

The above temperature range may be significant in terms of its potential influence on the exudate viscosity, as fluid viscosity is strongly temperature‐dependent. 75 The most common formulation of this relationship is the Andrade equation, η = α e β/ T , which indicates that the viscosity of fluids η decreases as the temperature T increases ( α and β being empirical constants).

Thus, risk factors for breast cancer have been identified that may be significant. 5.

In agreement with studies on fibroblast cell lines [ 51 , 52 ], we also noted that dexamethasone attenuated the release of gelatinase activity from PASMCs and this may be significant in the light of recent findings indicating that prednisolone selectively inhibits the proliferation of PASMCs from patients with idiopathic PAH [ 53 ].

While results from ANCOVA indicate whether an intervention is significant on average, it remains an open question whether the intervention's effect may be significant for one specific subgroup, but not another.

Thus, the light attenuation may be significant.

Nonetheless, a modest impact on TNFα production may be significant, as positive feedback loops leading to enhanced TNFα production might amplify the impact of this SNP in vivo [33] .