The χ 2 test was statistically significant, but it is well known that the test may be significant in large samples even though the magnitudes of model-data discrepancies are slight.
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This raises the possibility that the difference between INMT-C168 and NNMT-A168 may be significant in determining the distinct activities of INMT and NNMT.
For example, some risk factors, including women smoking, previous obstetric history, genital tract infection, etc., may be significant with PTD as well, yet the data were not available.
Our findings provide new insights into evolutionary adaptations to processing folate across various taxa, which may be significant in studies focusing on evolutionary genetics of drug metabolism.
They may be significant antioxidants with the ability to protect health and prevent disease [ 12 ].
Although the number of these mutations that have been sequenced to date is small it may be significant that missense point mutations are enriched at highly conserved residues, such as H1801P or L1815P, in comparison with non-sense and frameshift mutations ( Zentner et al, 2010 ) ( Figure 7B ), suggesting the structural integrity of the SLIDE domain could be important for the activity of CHD7 in development.
The readout errors for node size are rare while the readout error rate for the node properties shown as colors may be significant.
The cooperative motions of the Site3 GlcNAc and the Phe410 side chain may be significant from the mechanistic viewpoint.
This could be due to isotropic encoding measuring average ADC changes over all spatial directions (therefore including the smaller changes in diffusion parallel to fibres), in contrast with linear encoding measurements which may be significant only when maximally sensitive to fibres perpendicular to the diffusion encoding direction.
It may be significant that cancer stem cells (CSCs) that account for tumor initiation, metastasis, and resistance to many forms of therapy can attract Treg and lead to the expression of immunosuppressive IL-10 [ 16 , 17 ].
However, necessity of follow-up visits to healthcare professionals and parenteral administration of some anemia treatments (ESAs, iron) may be significant obstacles to many patients not on dialysis.
The results suggest that βIII-tubulin, survivin, and CA IX may be significant drug resistance markers and the clinical regulation of their activity may be an effective means of reversing this resistance.
If the findings can be replicated in future work, implications for adolescents and young adults with substance use problems may be significant.
Taken as a whole, the identified differences in grief trajectories based on the completion of LWs in patients versus DNR orders in caregivers point to the possibility that there may be significant variation in how various forms of ACP are differentially perceived and interpreted by patients and caregivers.
These findings may be significant, as although moxifloxacin and linezolid generally show limited activity against MAC, they can serve as important second-line treatment options.
While too few studies exist from which to draw firm conclusions, research conducted thus far suggests that there may be significant gender differences and it is likely that age may also play a role in the association between BMI and adverse mental ill-health status.
As the most prevalent phenotype found in both communities results in a competitive advantage for one isolate with a disadvantage for its pairwise competitor (+,-), these data suggest that antibiotics may be significant to mediating resource competitive interactions even at subinhibitory concentrations.
Although clinical outcome measures may already be routinely administered, there may be significant missing data, resulting in systematic bias if there is a lack of follow-up data on clients discontinuing therapy.
This negative dose bias may be significant when fluence delivery is complex.
It may be significant, therefore, that TPC2 gating and thus autophagy may be modulated by mTOR 31 , 66 .
Furthermore, studies suggest that preadipocytes and ASCs may be significant sources of proinflammatory mediators, such as CCL2 [ 12 ].
It is possible that small differences in deep sedation during the first 48 hours of critical illness may be significant in certain patients, particularly those who only require brief periods of mechanical ventilation.
Moreover, the Axon guidance pathway, Endocytosis pathway, T cell receptor signaling pathway, and Hippo signaling pathway were identified and may be significant mechanisms involved.
With long-distance migrants spending a significant proportion of their annual cycle on migration [ 8 ], the distance and duration of migratory movements may be significant factors influencing the susceptibility of species to these threats [ 1 , 9 ].
Note that it is difficult to obtain other omics (such as scATAC-seq, snmC-seq, and lncRNA-data) that can be paired with scRNA-seq data, and there may be significant technical and biological noise between different omics of single-cell sequencing data.