“may be significant”

Going forward, trials on AF-CA in HF should work toward including more female participants and at least assessing for the effect of gender on outcomes as there may be significant gender-based differences.

Inspection of the figures provided in Fuller et al [ 12 ] suggests that there may be significant errors in the alignment and labeling of data displays critical to evaluating the claims of the study. 1a.

Equally, changes in the genes involved in core functions such as gene expression and DNA metabolism may have pleotropic effects and there may be significant differences in strain behaviour, that are not simply the consequence of differences in their respective gene complements.

It may be significant that advanced UBC in men had higher androgen response activity across all luminal subtypes, compared to advanced UBC in women [ 85 ].

Therefore, the cavity shape of the periphery of heme may be important for saddling distortion, whereas the protein structure surrounding the Fe atom may be significant for doming distortion.

We also measured the cuticular transmission, which, although relatively large, is unlikely to contribute profoundly to ocellar function, but may be significant in determining the mean activity level of completely blinded cockroaches.

Patients with acute infection or sepsis, heart failure (HF), pulmonary embolism, severe valvular disease (moderate mitral stenosis and all other serious valve diseases and prosthetic valve disease), malignancy, coagulation disorder, patients younger than 18 years of age, acute or chronic stroke, depot diseases (glycogen, lipid, and lysosomal), acute kidney disease, mechanical valve, end-stage renal disease, severe anemia, recent acute patients with coronary syndrome (first 6 months) or CAD leading to stenosis, which may be significant, were excluded from the study.

17 Considerable initial weight reduction 18 and close follow-up, particularly in the early phase, 19 may be significant factors.

Stage III: During this stage (72–96 h), there may be significant hepatic dysfunction with kidney failure, coagulopathies, jaundice, hyperammonaemia, bleeding diathesis, and hepatic encephalopathy (confusion) [35] , [51] .

Furthermore, there may be significant variations in formulations (particularly the salt concentration), quality of raw ingredients and protocols for storage and distribution that may influence the final microbial safety and quality of the product. 4.2.

The systemic effects of ICSI may be significant, as studies have shown that they suppress the hypothalamic-pituitary-adrenal axis, potentially impairing the body’s response to stress 2 , 3 .

In reality, there may be significant correlations between individuals’ adherence to treatment from round to round or heterogeneity in adherence within an age group and country site.

Orthopedic injuries requiring operative fixation may indicate that these injuries resulted from such a high-energy mechanism that the stresses imposed by surgery at their current state of health may be significant.

The results of the research addressing gender (discussed above) do suggest, albeit indirectly, that such social and familial impacts may be significant.

Of these components, only κ i 1 can significantly contribute to the evolution of lattice orientation along a crystal line, whereas the κ i 2 components affect the transverse crystal orientation (which may be significant for planar architectures [ 39 ] ).

It has been reported that following SARS-CoV-2 infection, not only are antibodies against the SARS-CoV-2 S-protein produced, but also autoantibodies against ACE2, which may be significant for the development of long COVID after SARS-CoV-2 infection [ 96 , 97 , 98 , 99 , 100 ].

Development of intervention method on orexin system by different administration routes especially for injected opiate addicts at detoxification phase may be significant and was welcome. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY 1.

Both picozoa and choanozoa are known suspension feeders ( 36 , 37 ), where particle ingestion is nonselective and related to a minimum prey size ( 25 , 38 ), which indicates that these groups may be significant predators of viral particles in the marine environment.

Although, based on preliminary research, this study has shown that certain foods, nutrients, and dietary patterns may be significant determinants of the biological integrity of TL and that their high or low intake can affect TL dynamics during childhood and adolescence.

The spheroidal 3D structure of gliomas may be significant.

Consulting people who will be affected by research policies in this way is widely recognised as morally and practically important, particularly where there may be significant differences between researchers and those who participate in studies, for example, in their technical knowhow, wealth, culture and language ( Emanuel, Wendler, Killen, & Grady, 2004 ).

The accumulated data show that serum proteins are under strong genetic control and closely associated with diseases of different aetiologies, which in turn suggests that serum proteins may be significant mediators of systemic homeostasis in human health and disease.

26 This unique structure of IgG 4 may be significant for the FVIII-mimetic activity of our bispecific antibody, and the result suggests that the Ser228Pro mutation may not change the tertiary structure of IgG 4 dramatically.

This study yielded three key findings: first, compared to individuals with high SES, those with medium and low SES had a 30% and 75% increased risk of total microvascular complications; second, this positive association was also observed for individual microvascular complications; third, body mass index and other obesity‐related indicators, as well as glycated hemoglobin may be significant mediators of the association between SES and microvascular complications, with lifestyle factors having relatively smaller mediating proportions.

The cooperative motions of the Site3 GlcNAc and the Phe410 side chain may be significant from the mechanistic viewpoint.