Barely Significant
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“marginal significance”

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p=0.07

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

marginal significanceP = 0.061.2× alphagold
Inflammatory bowel disease, RA, and MS are Th1-related autoimmune disorders, meta-analyzing across these three traits yielded to a reduced effect with marginal significance [OR meta (95%CI) = 0.79 (0.63–1.01), P = 0.06 using all IVs; OR meta (95%CI) = 0.70 (0.51–0.95), P = 0.02 using IVs excluding confounders].
marginal significancep=0.061.2× alphagold
In men, socioeconomic differences decreased with income over the past 14 years (1.64, 1.09 to 2.49 in 2001; 0.99, 0.71 to 1.39 in 2014, RII, 95% CI, p=0.04), whereas inequalities were increased with marginal significance among women during the same period (1.48, 0.89 to 2.46 in 2001; 2.91, 1.98 to 4.29 in 2014, RII, 95% CI, p=0.06, by education; 1.22, 0.73 to 2.04 in 2001; 2.32, 1.63 to 3.30 in 2014, RII, 95% CI, p=0.056, by income, respectively; table 5 ).
marginal significancep = 0.061.2× alphagold
The median Health Assessment Questionnaire-Disability Index (HAQ-DI) after 3 months of TCZ treatment decreased from 1.13 only to 0.63 in group H IL-6i , whereas in group L, it decreased from 1.25 to 0.19, with numerically greater difference in group L with marginal significance ( p = 0.06).
a numerical trendp=0.0601.2× alphagold
When the data were stratified by autoantibody positivity (RF, ACPA) ( online supplemental table S1–S2 ), high PM 10 exposure showed a numerical trend towards a positive association with RA-ILD mortality in the RF (+) (HR 1.54; 95% CI 0.98 to 2.42; p=0.060) and ACPA (+) (HR 1.58; 95% CI 0.99 to 2.51; p=0.054) groups; but with marginal significance.
marginal significancep = 0.061.2× alphagold
Only 32 variants (7 BRCA1 and 25 BRCA2 ) were present in both cases and controls and these were analyzed for association with breast cancer risk (Tables 2 and 3 ). In the single-variant association testing using logistic regression, BRCA1 p.Arg762Ser was associated with breast cancer risk with a marginal significance (OR = 7.4; 95% CI, 0.9–62.3; p = 0.06) (Additional file 2 : Figure S1).