“highly significant”

This test yielded highly significant results for both similarity types (Functional and Taxonomic) across all three runs (Taxonomic: H-statistic 80.64–107.68.64.68, p < 1e-16; Functional: H-statistic = 380.5–457.7, p < 1e-80), indicating that at least one category distribution differed from all the others.

STRING analysis reveals a highly significant clustering ( p = 1 × 10 −16 ) of over 90% of the proteins identified ( Figure 7 ), with the existence of sub-clusters related to ER protein quality control, mitochondria membrane protein translocation, nuclear import, and stress granules.

The association of ZEB1 with promoters as well as with CpG islands and exonic regions is highly significant at a genome-wide scale (p < 10 −16 , Supplementary file 1D [ Gubelmann et al., 2014 ]).

Statistical analysis revealed a highly significant PPI enrichment ( p ‐value < 1e −16 ).

We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.

The correlation is weakly negative ( R S = −0.18) but highly significant ( p <10 −16 ) because the number of points is so large.

Initial mapping using an imputed genotype matrix for 2029 accessions (Togninalli et al ., 2018 ) revealed a highly significant peak associated with symptom score and total SA levels (−log 10 ( P ) = 15.96 and 10.64, respectively) spanning over 10 Kb on Chromosome 2 (Figs 1 , S2 for SA) and one marker reaching significance on Chromosome 3 (−log 10 ( P ) = 7.59) that is only associated with symptom score.

AgeAccelGrim remains a highly significant predictor of lifespan after restricting the analysis to never-smokers (N=3,988, meta analysis P=1.1E-16, Supplementary Fig. 9 ) or to former/current smokers (P=3.5E-33, Supplementary Fig. 3A ).

The M3 from the Japanese cohort wholly covered all the genes involved M11 from the TCGA cohort, which is highly significant overlap (n=41, hypergeometric test, P < 1.1e-16, Figure 2 g).

Irrespective of clades, all strains treated with 4 wt%Ag/TiZSM-5 zeolite and Ag-silicalite-1-nanomaterial showed highly significant inhibition for both biofilm [(24 h; F = 57.4079 and p = 1.1102 × 10 −16 ) (48 h; F = 43.3833 and p = 1.1 × 10 −16 ) and planktonic C. auris, compared to the control conditions.

It was found that the level of significance was highly significant ( P = 1.1102e-16).

The enrichment of SRCAP variants in the Caribbean Hispanic patients with LOAD was highly significant at p = 1.19e-16.

As shown in Table 1 , the pMHCs that induced higher contact areas also induced more rapid initial spreading, although the initial spreading rate displayed only 1.8-fold variation depending on stimulation peptide, but peptide discrimination remained highly significant ( p = 1.3 × 10 −16 ).

During the active period with lights off there was a highly significant difference between males and females (p = 1.3E-16) and also some difference between sites (p = 1.1E-3) with a significant interaction between site and sex (p = 3E-6) ( Fig 6a and 6b ).

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).

Highly significant increases in median nFLAIR, CNI, and CCrI were observed for NAV→NEL ( p = 1.5 × 10 –16 , 2.4 × 10 –15 , 2.8 × 10 –16 , respectively) voxels compared to stable NAV voxels, while increases in median nADC also reached a statistical significance of p = 0.0009.

In the univariate model, PIP (chosen to represent all other heart rate fragmentation measures) demonstrated a highly significant ability to predict mortality (p = 1.71E-16).

For males both age and puberty score were highly significant in predicting height at age 11 (r 2 = .17, p<2e −16 ) and 14 (r 2 = .23, p<2e −16 ).

The intercept had an estimated coefficient of 0.8443, which is highly significant (p < 2e-16), indicating a strong positive relationship between the dependent variable and the constant term.

Thus, although the number of substitutions in a partition is a highly significant ( P < 2e-16) predictor of passing or failing any of the tests, that it explains only about a quarter of the variation suggests that other factors, such as underlying differences in the extent to which partitions violate the SRH assumptions, are driving the remaining ∼75% of the variation.

The Shetland Sheepdog ranked second in all models, and both Collies and Shetland Sheepdogs were highly significant according to the logistic regression model ( p < 2 × 10 −16 ).

There was a highly significant effect of time for both sides ( p < 2e-16).

All p -values for the correlation coefficient are highly significant ( p -value < 2.0 × 10 −16 ).

We found that both RM and n sites had a highly significant effect (respectively, F 9,449 = 71, P < 2 × 10 −16 and F 1,449 = 103, P < 2 × 10 −16 ), and the interaction between RM and n sites was also significant ( F 9,449 = 8.99, P < 2 × 10 −16 ).

This overlap is highly significant ( P < 2 × 10 −16 ).