“highly significant”

The PPI network showed a highly significant enrichment with a p-value of <1.0e −16 and an average local clustering coefficient of 0.707.

The Moschus –VRTI network comprised 71 nodes and 547 edges, with a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

As illustrated in Figure 3 , there was a highly significant correlation between the genetic and transcriptome covariances for this set of genes ( r = 0.035, P = 1.0 × 10 −16 ; Figure 3 ).

Protein-protein interaction (PPI) analysis using STRING ( Szklarczyk et al., 2019 ) revealed that the hub proteins, including MSN, EZR, C1qa, a key component of the complement cascade, and GFAP, belong to a PPI network with highly significant interactions (p-value = 1.0e-16) ( Figure 4 B).

The network displayed an average target degree of 4.97 and a local clustering coefficient of 0.514, indicating a highly significant PPI enrichment (p-value <1.0e-16).

This enrichment in interactions was further supported by a highly significant PPI enrichment p -value of <1.0 × 10 −16 , indicating that the proteins in our network have more interactions among themselves.

Notably, only proteins associated with our list of cKO- Eed -MADM–specific DEGs, but not sparse Eed -MADM–specific DEGs, formed a highly significant and densely connected network (PPI enrichment P value < 1 × 10 −16 ) (fig.

It further confirmed that the association of clock PRRs with flowering control genes was not random and connected with a highly significant value of p < 1 × 10 −16 .

The network comprised 87 nodes and 1, 198 edges and showed highly significant enrichment (PPI enrichment p < 1.0 × 10 -16 ).

Results Strong, negative association between elevation & lung cancer incidence Performing best subset regression for each cancer, we found a highly significant, strong negative association between elevation and lung cancer incidence with a standardized coefficient ( β z ) of −0.35 99% CI [−0.46, −0.25] ( p < 10 −16 , one-tailed t -test) ( Table 2 ).

This overlap is highly significant ( P -value <10 −16 , hypergeometric test where the intersection is 9000 between 700 000 conserved islands and 60 000 DHSs, assuming a total of 30 000 000 potential loci), consistent with the idea that sequence conservation at overlapping unannotated conserved island/DHS loci reflects the importance of regulatory factor binding to DNA.

The interaction between fingertip ROI and stimulation condition was highly significant ( F 16,80 = 71.7, P < 10 −16 , Greenhouse‐Geisser correction: F 1,5 = 71.7, P < 10 −3 ).

A highly significant proportion of these genes (Figure 4A and B and Supplementary file 5) (599, hypergeometric P < 1e−16) are also within 25 kb of 961 TP53 binding sites, potentially representing direct TP53-induced target genes (Figure 4B and C ), many of which, such as CDKN1A , are associated with multiple TP53 sites.

The regression itself was highly significant ( R 2 = 0.93, P < 10 −16 ), and outliers were those points lying above or below a 99.9% confidence interval around the line of best fit.

The global mediation test reveals a highly significant result ( p < 10 − 16 ) and low neutralization rate (21%), confirming that CT imaging strongly mediates the effect of PRS on FEV1.

Moreover, pairwise Levene’s tests for equality of variances between ancestry tracts were all highly significant ( p < 1 × 10 −16 ).

For our list of 64 miRs, 18 enrichment pathways are highly significant ( p < 1E-16).

Again, the correlation between the P values of the 1000 top variants for the classical and mixed-effect Cox models was highly significant ( r = 0.97, Spearman P value < 10 −16 (Supplementary Fig. 4b )).

Moreover, the Pearson correlation between association strength of shared SNPs across the two tissues was highly significant ( P <10 −16 ), highlighting the conservative genetic architecture of C18∶1, C18∶3, C20∶0 and C20∶1 in the two tissues.

For the secretome of ET-eMSC, the enrichment of low and high abundance proteins was highly significant ( p < 10 −16 ).

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

The perfect association of the haplotype was highly significant (p<10 −16 ).

Functional network analysis of BAs: insights from protein–protein interaction (PPI) analysis The PPI analysis conducted using the STRING database revealed a highly significant enrichment of interactions among the analyzed proteins (PPI enrichment p-value < 1.0e−16), indicating a biologically relevant network rather than a random association.

The difference in degree of nucleotide conservation between the IDR and the remainder of the molecule is highly significant ( P <10 −16 ), and indicates a dramatically higher level of divergence for the IDR-encoding portion of the mammalian TS transcript.

The network comprises 26 nodes and 131 edges, with a highly significant PPI enrichment p < 1.0e-16.