“highly significant”

Across all 10‐kb windows in the genome, there was a weak but highly significant correlation in the distribution of Tajima's D values in the two clusters (Figure 4 b; Spearman's ρ = 0.25; p < 10 −16 ).

The network showed strong biological relevance with highly significant enrichment ( p -value < 1.0e-16).

However, while the difference between term and moderate to late preterm TREC was significant but not meaningful, 108 (70–170) vs 101 (64–164) median TREC ( p = 0.0017), the differences between term and extremely preterm, 49 (29–92), or very preterm, 88 (52–149), were both highly significant ( p = 1E −16 , p = 4E −6 , respectively) and meaningful.

ChIP-seq showed there was a highly significant correlation ( p values < 10 −16 ) between ER binding fold changes induced by the addition of elacestrant or fulvestrant in the three cell lines tested (Pearson correlations with p values <10 −16 ; 0.78 MCF7, 0.47 MCF7-LTED wt and 0.60 MCF7-LTED Y537C ) especially in regions where there was increased ER binding after treatment versus E2 (Fig. 4A ).

The association of ZEB1 with promoters as well as with CpG islands and exonic regions is highly significant at a genome-wide scale (p < 10 −16 , Supplementary file 1D [ Gubelmann et al., 2014 ]).

Despite the different experimental conditions, we found a highly significant overlap (odds ratio [OR] = 27, P < 10 −16 ) ( Fig. 1 C).

After removal of disconnected nodes, the refined network consisted of 267 nodes and 1154 edges, with an average degree of 8.64 and a highly significant PPI enrichment ( P < 1.0e-16).

Indeed we observed for all species a highly significant correlation between GC content and thermodynamic stability and folding strength (Spearman’s rho =0.239, p -value <10 -16 for all lincRNAs considering folding strength) as observed in [ 49 ].

This was observed in both sexes These differences in T2D prevalence between the three groups were highly significant (Chi square test p -value < 10 −16 ).

Figure 3 illustrates the interactome for DS3, featuring 257 edges, 57 nodes, an average node degree of 9.02, and a highly significant PPI enrichment p -value of <1.0 × 10 −16 .

The Moschus –VRTI network comprised 71 nodes and 547 edges, with a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

The perfect association of the haplotype was highly significant (p<10 −16 ).

Next-generation sequencing in pooled samples from patients with Crohn's disease and controls identified additional independent risk variants in two of the known risk genes ( NOD2 and IL23R ), a highly significant association with a protective splice variant in CARD9 ( P < 1 × 10 −16 , odds ratio ∼0.29), and additional associations with coding variants in several genes ( IL18RAP , CUL2 , C1orf106 , PTPN22 and MUC19 ) ( Rivas et al. , 2011 ).

Moreover, pairwise Levene’s tests for equality of variances between ancestry tracts were all highly significant ( p < 1 × 10 −16 ).

This difference between MS patients and non-MS controls is highly significant ( p < 10 − 16 ) .

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: [email protected].

The resulting network comprised 332 nodes and 1181 edges, with a highly significant PPI enrichment p -value < 1.0 × 10 −16 , indicating a non-random and biologically meaningful set of interactions.

For our list of 64 miRs, 18 enrichment pathways are highly significant ( p < 1E-16).

However, the overlap between the two categories of the interagency transcribed regions is highly significant ( P -value < 10 -16 , chi-square test).

Notably, the results of this analysis showed that the majority of the proteins (73 of the 81 submitted proteins) are connected within a single network, with a highly significant protein-protein interaction enrichment (p-value < 10 −16 ) (Fig. 1A ).

The network displayed an average target degree of 4.97 and a local clustering coefficient of 0.514, indicating a highly significant PPI enrichment (p-value <1.0e-16).

Moreover, the Pearson correlation between association strength of shared SNPs across the two tissues was highly significant ( P <10 −16 ), highlighting the conservative genetic architecture of C18∶1, C18∶3, C20∶0 and C20∶1 in the two tissues.

The discovery and validation gene counts were 2.8 and 1.2 enriched respectively in the 38 Cluster 2-like NPH astrocytes and highly significant (chi-square test of expected versus observed UMIs; p < 1E-16).

Statistical analysis (MANOVA) of the original data obtained from the cell populations indicated a highly significant difference between them (p<10 −16 ) suggesting that the nuclear SIRT1 pattern reflects structural differences in the nuclei between the cell populations.

The correlation between the distance of GO groups in the 0.001 cutoff co-evolution network (that is, their evolutionary distance) and their distance in the corresponding GO ontology network (that is, their functional distance) is highly significant: 0.38 for cellular component, 0.16 for biological process and 0.43 for molecular function (all three with P -values <10 -16 ; a similar trend is observed using the 0.01 cutoff network).