“highly significant”

Using STRING analyses, we identified a highly significant protein–protein interaction (PPI) enrichment ( P = 10 −16 ) only for the downregulated genes of H2A.Z.1‐depleted cells.

In Silangit, the most discriminative metabolites were tromethamine, oxalacetic acid, adenosine, phenylacetaldehyde, and bis(2-ethylhexyl) phthalate, all of which showed highly significant differences ( p < 1.0 × 10 −16 ).

In particular, there was a highly significant overlap ( p < 1E-16, one-sided Fisher’s exact test) between the top 56 enriched cytobands from the CBTN cohort and a top set of 79 enriched cytobands from the PCAWG cohort, involving 29 cytobands (Figure S1e).

The difference in degree of nucleotide conservation between the IDR and the remainder of the molecule is highly significant ( P <10 −16 ), and indicates a dramatically higher level of divergence for the IDR-encoding portion of the mammalian TS transcript.

The network comprises 26 nodes and 131 edges, with a highly significant PPI enrichment p < 1.0e-16.

In other words, organisms sampled from a defined skin habitat were more similar to each other in 16S sequence than expected for a global background; this enrichment was statistically highly significant (p<<10 −16 , one-sided Mann-Whitney-U test, see Table S1 ).

The resulting network showed a highly significant interaction among the proteins (p value < 1.0e −16 ).

The overall PPI enrichment was highly significant ( p -value < 1.0e-16).

Again, the correlation between the P values of the 1000 top variants for the classical and mixed-effect Cox models was highly significant ( r = 0.97, Spearman P value < 10 −16 (Supplementary Fig. 4b )).

In each of the hippocampus, amygdala, thalamus, caudate, nucleus accumbens, and brainstem, one or more diffusion metrics were highly significant with P < 10 −16 .

Notably, the results of this analysis showed that the majority of the proteins (73 of the 81 submitted proteins) are connected within a single network, with a highly significant protein-protein interaction enrichment (p-value < 10 −16 ) (Fig. 1A ).

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

For statistical evaluation, we computed the mean Spearman correlation ( ρ ) between predicted and measured gene expression profiles on held-out genes for each tumor type and obtained mean ρ = 0.384 ± 0.016 for PSIONIC, a highly significant result ( P < 10 −16 , one-sided Wilcoxon signed-rank test).

The 48 proteins consistently enriched in plaques in both EOAD and DS also showed a highly significant degree of protein–protein interaction ( p < 1.0 × 10 –16 ; Fig. 3 D) and were almost exclusively classified as either vesicle (enrichment FDR: 4.32 × 10 −9 ) or extracellular proteins (enrichment FDR: 3.34 × 10 −8 ).

There were highly significant differences in flowering ( F 3, 379.07 = 473.2, P < 1 × 10 −16 ) and green-up ( F 3,416.03 = 110.5, P < 1 × 10 −16 ) among the grandparents.

These results show that all four topological measures provide highly significant ( p -value < 1e-16) enrichment in pathogen targets, with betweenness and clustering coefficient displaying highest enrichment, thereby demonstrating the added value of incorporating PPI data into inferred networks for a generalizable approach to identify target regulatory nodes within networks.

While the correlation between studies was moderate (0.36), it was highly significant ( P < 1 × 10 − 16 ), demonstrating that a high degree of APP co-splicing across the genome was reproduced between studies.

ChIP-seq showed there was a highly significant correlation ( p values < 10 −16 ) between ER binding fold changes induced by the addition of elacestrant or fulvestrant in the three cell lines tested (Pearson correlations with p values <10 −16 ; 0.78 MCF7, 0.47 MCF7-LTED wt and 0.60 MCF7-LTED Y537C ) especially in regions where there was increased ER binding after treatment versus E2 (Fig. 4A ).

Moreover, pairwise Levene’s tests for equality of variances between ancestry tracts were all highly significant ( p < 1 × 10 −16 ).

One-way analysis of variance (ANOVA) using the cluster size as the factor variable found that both results are highly significant ( P < 10 −16 ).

Follow up genotyping of 70 rare and low-frequency protein-altering variants (MAF ~ .001-.05) in nine independent case-control series (16054 CD patients, 12153 UC patients, 17575 healthy controls) identifies four additional independent risk factors in NOD2 , two additional protective variants in IL23R , a highly significant association to a novel, protective splice variant in CARD9 ( p < 1e-16, OR ~ 0.29), as well as additional associations to coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19 .

Protein–protein interaction (PPI) analysis revealed a highly significant network connectivity among these proteins ( p < 1.0 × 10 −16 ).

The analysis revealed a highly significant interaction network among the differentially abundant proteins ( p < 1.0 -16 ), indicating that down-regulation of these protein interactions may play a crucial role in modulating intracellular biological processes in pigs fed a BET diet. 3.2.

Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).

The resulting network comprised 14 nodes and 87 edges with a highly significant enrichment (p-value <1.0e–16), indicating nonrandom functional connectivity among apoptosis, inflammation, and oxidative-stress regulators.