“highly significant”

The correlation between RNA-seq fold changes computed on the data from day 2 versus that from day 4 was highly significant (r = 0.50, P<10 −16 , Figure S2A ).

We do detect a highly significant enrichment of marine-freshwater differentially expressed genes, as predicted ( P < 10 −16 ).

The discovery and validation gene counts were 2.8 and 1.2 enriched respectively in the 38 Cluster 2-like NPH astrocytes and highly significant (chi-square test of expected versus observed UMIs; p < 1E-16).

In sharp contrast, the STRING analysis found a highly significant connection enrichment in the MSI-H overexpressed proteins ( Fig. 3 B ; p -Value < 10 −16 ).

A highly significant correlation (half-life: Spearman's r = 0.67, P ≤ 1e -16 ; decay rate: r = 0.64, P ≤ 1e -16 ) was obtained, supporting the initial finding that RNA stability becomes more pronounced with increasing distance from the promoter.

They were not identical to the ones identified in each disease individually, but showed a highly significant overlap in both cases ( p < 1E−16, χ 2 -test).

41 All clocks demonstrated a strong and highly significant correlation with the biologic age, with the skin and blood clock demonstrating the strongest correlation (Pearson R = .96; 95% CI, 0.959–0.97; P <1 × 10 16 ) ( Figure 8 A ).

The network comprised 65 nodes and 400 edges, with a highly significant PPI enrichment p-value of < 1.0 × 10−16(Fig. 1 B).

Moreover, using paired t tests to validate these differences, we found highly significant differences between the observed distributions of FD and PD and the null models ( P < 10 −16 , t test).

For the secretome of ET-eMSC, the enrichment of low and high abundance proteins was highly significant ( p < 10 −16 ).

As expected, our meta-analysis confirmed a highly significant association between the GTF2I rs117026326 polymorphism and pSS (OR = 2.17; 95% CI = 2.00–2.34, p < 1 × 10 −16 ) ( Figure 4 A).

The network displayed an average target degree of 4.97 and a local clustering coefficient of 0.514, indicating a highly significant PPI enrichment (p-value <1.0e-16).

In contrast, highly significant differences were observed between promoter usage in ΔCTCF-HPV18 episomes compared to HPV18 following keratinocyte differentiation (p < 1E-16).

By a STRING protein-protein interaction network analysis of proteins identified by MS, we determined a highly significant network of proteins being bound to the nimtRNA transcript ( p < 1.0e−16).

In Silangit, the most discriminative metabolites were tromethamine, oxalacetic acid, adenosine, phenylacetaldehyde, and bis(2-ethylhexyl) phthalate, all of which showed highly significant differences ( p < 1.0 × 10 −16 ).

Interaction network and functional enrichment of differentially abundant proteins The interaction network between the DAPs was highly significant (p-value < 10 −16 ), indicating that the DAPs are at least partially biologically connected (Fig. 2 ).

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

The Moschus –VRTI network comprised 71 nodes and 547 edges, with a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

The network showed highly significant PPI enrichment (p < 1.0 × 10 −16 ), with an average node degree of 3.52 and a local clustering coefficient of 0.497, supporting the presence of a non-random and moderately clustered interaction structure.

Accordingly, the removal of these functional factors leads to a highly significant association between GC content and recent positive selection (slope = 0.49; P < 1E−16; supplementary Results S3: table S4, Supplementary Material online).

This test yielded highly significant results for both similarity types (Functional and Taxonomic) across all three runs (Taxonomic: H-statistic 80.64–107.68.64.68, p < 1e-16; Functional: H-statistic = 380.5–457.7, p < 1e-80), indicating that at least one category distribution differed from all the others.

We have applied a statistical test and found that all of the comparisons of short gene expression to longer gene expression are highly significant (p-values <10-16, Kolmogorov-Smirnov test).

The heritability estimates for all subfields, displayed on the plot’s diagonal, were highly significant (all p -values < 1 × 10 −16 ), ranging from h 2 = 0.14 of the parasubiculum to h 2 = 0.27 for the hippocampal tail.

One-way analysis of variance (ANOVA) using the cluster size as the factor variable found that both results are highly significant ( P < 10 −16 ).

By enhancing the confidence levels of the PPI to the highest level (0.9), the number of edges decreased to 2534 and the node degree average to 8.11, but the PPI enrichment remained highly significant ( p < 1.0 × 10 −16 ), underscoring the quality of the proteomic data.