“highly significant”

The bidirectional relationship between CBF and CMRO 2 was highly significant ( p = 0.00023), and both contributed to the changes in OEF.

The trend to increased cataract score with age was highly significant ( P = 2.3 × 10 −4 ).

the threshold of 0.44 is highly significant (p-value = 2.3 × 10 -4 ).

The difference was already highly significant at 1 h (*** p = 0.000232), and became even more pronounced at 24 h (**** p = 0.000005).

Once both of these classes of tumors were removed, the correlation between the two estimates of lifetime mutation accumulation in the remaining 28 tumor types was highly significant ( P = .00024, r=0.64).

The differences were highly significant with the Kruskal-Wallis test (p = 0.00024).

Out of the 24 highly significant metabolites 14 (58%) could be confirmed at the high (p < 0.00024) and 19 (79%) at the normal (p < 0.05) significance level (figure 4 ).

Statistical testing of the overlap among the peaks of these datasets and our Satb2 ChIP-seq data revealed highly significant enrichment (adjusted p<0.00024) of active chromatin states (H4K16ac, H3K27ac, H3K4me1, H3K4me2, and H3K4me3 peaks) and PolII peaks at Satb2-bound promoters ( Figure 5C , Figure 5—figure supplement 2A ).

The ANOVA of the Plackett-Burman design demonstrated that the model was highly significant as was evident from the Fisher’s F -test (51.910) with a very low probability value [ P- value = 0.00024] and the t -Stat of 493.355.

The corresponding OPLS-DA model was highly significant: R 2 X = 0.464, R 2 Y = 0.918, Q 2 = 0.567 and p = 0.00024 ( Figure 4 B).

Importantly, while the BV/TV values of sham-operated wild-type and PLCγ2 −/− animals were statistically highly significant ( P = 0·00025), there was no significant difference between the two genotypes after the ovariectomy procedure ( P = 0·25; n = 7 (wild type) vs. 4 (PLCγ2 −/− )).

The differences were highly significant (p < 0.00025).

The yield model was highly significant with a very low p=0.00025.

There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously published data on healthy individuals.

We find highly significant differences between groups in motor noise ( F = 8.7, p = 2.5e−4), driven by enhanced motor noise in the relatively ‘Low’ subtype compared to the relatively ‘High’ subtype ( t = − 3.2, p = 0.002, Cohen’s d = 0.77) and compared to TD children ( t = − 4.1, p = 1.33e−4, Cohen’s d = 0.85).

The Chao1 index showed highly significant differences among groups ( p = 0.00025), with the HFD group exhibiting markedly reduced microbial richness compared with the ND group.

Permutation tests showed that the effect of feeding treatment was highly significant for population growth rate ( p < 0.00025 ) and stable population structure ( p = 0.0012 ; Figure S3 and Table S1 ).

All four axes remained highly significant after conservative cross-family correction (all Holm-adjusted P < 2.5 × 10 -4 ), confirming that the convergent multi-omics signature associated with elevated Rad-Score — encompassing ferroptosis activation, effector immune infiltration, genomic instability, and spatially organized chemokine networks — is robust and independent of false-positive inflation across omics families.

Results were statistically highly significant ( P = 0.000251, Spearman Coefficient: 0.91815).

A robust negative correlation to IC 50 ( r = −0.504) was exhibited by the Number of Hydrogen Bond Donors (NumHDonors), accompanied by a highly significant p -value ( p = 2.56e-04), which was indicative of an association between a higher count of hydrogen bond donors and enhanced compound activity.

In contrast to TMX(-) studies, here we observed a highly significant interaction between Cre-ER and Lox-Stop (p=2.59E-4), which suggested that SynGAP re-expression altered activity suppression levels.

One comethylation module (Bisque 4) showed a highly significant negative correlation between sample eigennode values and ASD diagnosis ( P = 2.6E−4).

Kaplan–Meier analysis revealed a striking survival advantage for the high methylation group, with a highly significant difference in OS (log-rank p = 0.00026) (Fig. 2 d).

For example, there is a highly significant correlation between expORChID2 values and X-ray-derived minor groove widths for the Ubx-Exd heterodimer DNA binding site, because P = 0.00026 falls below a confidence level of 0.001.

The difference among body mass distributions of extinct, introduced, and remaining frugivore species was highly significant (ANOVA, F 37,2 = 10.343, p = 0.00027; Kruskal–Wallis Χ 2 = 16.477, p = 0.00026, see Supplementary Fig. 1 ).