“highly significant”

Both regressions were highly significant ( p -value = 0.0002 for seed viability and <0.0001 for seed counts).

To reduce the bias of time to HSCT2 we analyzed only patients having HSCT2 within 6 months of relapse and found that having HSCT2 was a highly significant predictive factor in this univariate analysis ( P =0.0002).

A linear model confirmed the expectations of a highly significant and increasing relationship ( t -value = 4.04, p = 0.0002, R-square 0.241).

The correlation between the clock time estimate and clock time setting deviations was highly significant ( r =−0.88, p < 0.0002).

Analysis of IL-18 (mean [min/max]: 2,385 [300–8,025] pg/ml) and ECP (mean: 1,509 [<100/4,625] ng/ml) in 23 paired samples showed a highly significant correlation (r s = 0.70, P = 0.0002) between this cytokine and the eosinophil-derived product in the airways.

This correlation is highly significant for the 24 non-agricultural strains ( r 2 = 0.47, P = 0.0002) while it was not significant for the 31 agricultural strains ( r 2 = 0.03, P = 0.33), suggesting that the relationship between aggressiveness and sclerotial production differ among these two populations of strains.

We performed qPCR analysis to detect the expression of AKAP12α and AKAP12β isoforms using isoform-specific primer sets and found less significant reduction in AKAP12β gene expression in tumor tissues (P=0.0594), whereas the reduction in the expression of AKAP12α gene in tumors was highly significant (P=0.0002) ( Fig. 1B ).

The clustering analysis based on network proteins showing increased levels in the NPM1-Ins patients showed that all except one of the patients with NPM1-Ins clustered together in the same main patient cluster, characterized by generally high levels of these proteins ( Figure 3 ); this difference in distribution of NPM1-Ins patients between the two main patient clusters is highly significant (Fisher’s exact test, p = 0.0002).

21 Comparing our 100 smoking genes identified in C‐SM versus C‐NSM with the top 25 smoking‐related genes identified in this previous meta‐analysis ( n = 25), we found three genes (GPR15, LRRN3, and CLDND1) overlapped, which is highly significant based on a hypergeometric probability test ( P < 0.0002).

This increase starts already at birth, remains constant throughout childhood s as shown by other groups ( 4 , 9 ) results in relative increase of the memorand adolescence, and is highly significant (linear regression intercept p = 0.0002, slope p = 0.54) (Figure 1 C). cTFHs Are Expanded in DiGeorge Syndrome To correct for the relative increase of memory CD4 + T cells in DiGeorge, we compared the percentages of CXCR5 + memory CD4 + T cells (cTFHs) of all memory CD4 + T cells (gating strategy shown in Figure 2 A).

Furthermore, the interaction between baseline FS and treatment arm is highly significant ( P =0.0002; Table 2 ).

In the extended model (Supplement Table 7), the significance level of β-blockers changed from non-significant ( p = 0.1205) to highly significant ( p = 0.0002) with an HR of 1.004.

However, when the cells were irra- diated, the slopes of the dose response for S2 and S3 cells were about twice that of F9 cells, indicating that MN fre- quencies after X-irradiation were consistently higher in cells overexpressing the bcl-2 gene and the differences were highly significant at the dose point of 4 Gy (P= 0.0002-0.002).

The difference between the means of the fold-inhibition values of TRIM22 shRNA (1.4-fold) and the pooled controls (4.5-fold) was highly significant (P = 0.0002 Mann-Whitney) ( Figure 3E ).

However, the highly significant difference between the relative occurrence of bacterial families in ME and E lakes (ANOSIM r = 0.99, p = 0.0002) leads to the conclusion that the meso-eutrophic lakes were inhabited by different groups of bacteria than the eutrophic ones.

For the Ncl window (240–285 ms), a highly significant main effect was found for condition ( p = 0.0002) and group ( p = 0.039) with higher GFP for the IC condition and in the group with 22q11.2DS.

This analysis showed a highly significant difference ( p = 0.0002), highlighting that fistulectomy improves the quality of postoperative evacuations by promoting more formed and regular stools than fistulotomy.

Cox regression with clustering on pedigree showed that the exon was a highly significant predictor (χ 2 19.75 with 3 degrees of freedom, p = 0.0002).

Upon quantification (Figure 6B ), this increase in mortality was highly significant ( p = 0.0002 as compared with TFN; p = 0.0089 as compared with PF477736 and p = 0.0245 as compared with camptothecin).

Regression analysis confirmed a highly significant correlation between expression of CXCL11 and TBET (p=0.0002), or Granzyme B (p=0.0055), respectively (Figure 4C ), but not between CXCL11 and GATA3, RORC or FOXP3 (not shown).

The nonlinear SUA–PSE association was preserved (P for nonlinearity < 0.001), and the nonlinear sex × SUA interaction component remained highly significant ( p = 0.0002), confirming that the sex‐dependent pattern is not attributable to severe‐stroke cases.

This meta-analysis failed to show any benefits of adjuvant bisphosphonates in premenopausal women, but highly significant improvements in bone recurrence (RR = 0.72; 95% CI 0.60–0.86, 2 p = 0.0002) and breast cancer mortality (RR = 0.82; 95% CI 0.73–0.93, 2 p = 0.002) were seen in the 11,767 postmenopausal women included in the meta-analysis.

Similarly, the improvement in criterion two, from 61% to 85%, was highly significant (p=0.0002).

Highly significant differences in overjet: - Both condyles Δ x ≥ 2 mm → p = 0.0002; - Δz ≥ 2 mm → p = 0.001 (left), p = 0.007 (right).

The overall multivariate model was highly significant (likelihood ratio test p = 0.0002, Wald test p = 0.0001), with a concordance index of 0.679, indicating good prognostic discrimination.