“highly significant”

We performed qPCR analysis to detect the expression of AKAP12α and AKAP12β isoforms using isoform-specific primer sets and found less significant reduction in AKAP12β gene expression in tumor tissues (P=0.0594), whereas the reduction in the expression of AKAP12α gene in tumors was highly significant (P=0.0002) ( Fig. 1B ).

The PRC diagram (highly significant, pseudoF = 52.3, p = 0.0002, Fig. 5 ) clearly demonstrated the responses to experimental manipulations.

No significant association was seen between dN/dS and expression kinetics, but a highly significant association was observed between protein product function and dN/dS (p = 0.0002).

A highly significant trend ( P = 0.0002) was reported.

The degree of the functional overlap across the six BR-signatures is highly significant (P = 0.0002) under a bootstrapped null distribution.

To reduce the bias of time to HSCT2 we analyzed only patients having HSCT2 within 6 months of relapse and found that having HSCT2 was a highly significant predictive factor in this univariate analysis ( P =0.0002).

The correlation between the clock time estimate and clock time setting deviations was highly significant ( r =−0.88, p < 0.0002).

In general, the difference in CYP2W1 expression between normal tissue and primary tumours was highly significant (P ≤ 0.0002).

For confirmation, we applied IFNA16 rs28368163 as a tag SNV in a second ET validation cohort (n = 54) and reconfirmed a highly significant association ( P = .0002) and OR (4.51; CI, 1.92-10.56), nearly identical to that found in Cohort 1 ( Table 2 ).

However, when we pooled data for each continental group and compared the sub-Saharan component across all genomes within that group with the estimated Neanderthal ancestry in the same genomes, we found a highly significant negative correlation for Western Asia (rho=−0.234, P < 0.0002; supplementary table S2 , Supplementary Material online).

A linear model confirmed the expectations of a highly significant and increasing relationship ( t -value = 4.04, p = 0.0002, R-square 0.241).

Furthermore, the interaction between baseline FS and treatment arm is highly significant ( P =0.0002; Table 2 ).

Therefore, it was found that the association between frequency of smokeless tobacco usage and the presence of oral mucosal lesions was highly significant (p= 0.0002*).

There was highly significant association between the number of drugs prescribed and frequency of use of PIMs ( P < 0. 0002).

This meta-analysis failed to show any benefits of adjuvant bisphosphonates in premenopausal women, but highly significant improvements in bone recurrence (RR = 0.72; 95% CI 0.60–0.86, 2 p = 0.0002) and breast cancer mortality (RR = 0.82; 95% CI 0.73–0.93, 2 p = 0.002) were seen in the 11,767 postmenopausal women included in the meta-analysis.

Interestingly, the difference in means of the HER2/CEP17 ratio was highly significant for MP high-risk versus low-risk tumors ( P = .0002; 95% CI for true difference in log-transformed means, 0.40 to 1.06).

1b ) revealed highly significant correlations of PC1 and PC2 with hepatic zones (PC1: r = 0.47, p = 2.0 × 10 −4 ; PC2: r = 0.86, p < 2.2 × 10 −16 , Supplementary Figure 3) indicating zonation as a major driver of variation between samples.

Analysis of IL-18 (mean [min/max]: 2,385 [300–8,025] pg/ml) and ECP (mean: 1,509 [<100/4,625] ng/ml) in 23 paired samples showed a highly significant correlation (r s = 0.70, P = 0.0002) between this cytokine and the eosinophil-derived product in the airways.

The LMM over HbO revealed both a highly significant main effect of Condition ( F (2, 437) = 8.59, η p 2 = 0.04, p = 0.0002), indicating that overall activations differed across Speech, Song and Hummed melody, as well as a significant Condition × Trial interaction ( F (2, 438) = 4.61, η p 2 = 0.02, p = 0.0104) (Fig. 4 ), indicating different trends between conditions across the time course of the experiment.

The analysis showed that the level of TMEM244 expression is negatively correlated with the square of the methylation level in the promoter region ( R = −0.4766), and this correlation is highly significant ( P < 0.0002) (Figure 4 ). 4 DISCUSSION In this study, we showed that methylation is a key regulatory mechanism of TMEM244 expression.

Highly significant differences were observed across all strata and between both lakes (p = 0.0002 for AP/BL; p < 0.0001 for surface/bottom layers).

There were pathogenic deletion variants in 5.26% of females and 3.69% of males, and this difference was highly significant (P < 0.0002) ( Fig. 2B ).

he difference between the experimental and control conditions was highly significant (paired t (4) = 13.50, p = 0.0002, Cohen’s d = 9.55).

This difference was highly significant (GROUP effect: F = 21.18; P = 0.0002; Fig. 3a ) and was apparent during both the ramp and hold phases, and at both force levels (P = 0.01).

This analysis revealed highly significant dependencies between FAA and the six EDA features (all p < 0.0002 ), indicating robust non-linear relationships.