The interaction between MLEC and TMEM59 was highly significant ( p = 0.00019, β = 2.469), with higher expression of both genes correlating with increased predicted probabilities ( Figure 10I ).
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Log-rank analysis showed a highly significant difference between the two groups ( P = 0.00019), indicating that the CPVI + PLUS strategy was more effective in reducing AF recurrence ( Figure 2K ).
Linear regression analysis showed that the slope of the line was not significantly different from zero for normal Aβ degradation when the threshold is four but it was highly significant ( p = 0.00019) for the AD degradation rate (Figure 4 A, B).
Cluster 35 shows a highly significant enrichment for genes associated with gene ontology (GO) terms involving neurogenesis (Additional file 8 : Table S2, P = 1.91 × 10 −4 ) consistent with the peak and decline of neurogenesis from E12.5 to 16.5.
The results were conclusive: only IL-18R1 maintained a highly significant direct causal effect on AD (β = 0.023, P = 1.92 × 10 −4 ), whereas the direct effects of both PA-GPC ( P = .074) and IL-18 ( P = .084) became non-significant.
A t-test was also performed to validate significant enrichment of repetitive elements in the intergenic regions which gave a highly significant p-value for the enrichment of repetitive elements in the intergenic regions (p-value = 0.0001957 in S . tuberosum and p-value = 6.018e-11 in S . lycopersicum ).
These correlations were highly significant ( p < 1.96 × 10 − 4 ).
The time domain features showed a highly significant distinction ( p -value = 0.0002), indicating a clear dissimilarity between the AD and baseline groups in this domain.
The H1: TAA noncarriers showed highly significant higher average procalcitonin levels (5.1 ± 9.7 ng/dL vs. 3.5 ± 9.1 ng/dL; p = 0.0002) as well as significantly lower urine outputs (2792 ± 1242 mL/day vs. 3060 ± 1370 mL/day; p = 0.0229) over the observation period than the H1: TAA-positive patients. 4.
A highly significant (p = 0.0002) effect on carcass weight was found for haplotypes detected on BTA12.
Between species, the overall effect was highly significant (Kruskal–Wallis χ 2 = 22.2, df = 4, P = 0.0002), with SL having highest diversity.
Pregnancy rate according to cleavage Further analysis of ETs with cultured embryos revealed that highly significant PRs were observed when ≥2 cleaved embryos were transferred (42.2%) than when 1 cleaved embryo (16.9%, P =0.0002) or embryos without cleavage were transferred (3.2%, P ≤.0001) [ Table 4 ].
However, lower pressure still resulted in highly significant release of the REMIS markers from the brain ( Fig. 2e , left-most panel, P = 0.0002, n = 7, ratio-paired t test).
After regression analysis was performed, the quadratic polynomial regression equation describing the effects of CAR/GEL mass ratio (A), CS concentration (B), and GSA/CUR dosage (C) on the comprehensive score (Y) was obtained as follows: (11) Y = 0.66 − 0.041A + 0.019B + 0.036C + 0.061AB + 0.075AC + 0.027BC − 0.054A 2 − 0.091B 2 − 0.054C 2 Analysis of variance (ANOVA) for the response surface methodology (RSM) experiments ( Table 7 ) revealed the following: The regression model was highly significant ( p = 0.0002).
A highly significant interaction emerged with factors WordType, PeriExtra, TempFront and Areas ( F 2, 22 = 14.012, p < 0.0002), revealing different CA circuits across the 12 area network between object- and action-related words.
Analysis of 27 benign and 23 pathogenic variants co-occurring at 22 residues again showed that the difference between the two groups was highly significant ( P = 0.0002) and that, as a group, pathogenic missense changes were more strongly destabilizing than benign ones at the same position (average ΔΔG value by group = 6.81 and 2.18 kcal/mol, respectively) [ Fig. 3(c )].
Though this gene has been used in the literature [ 39 ], performance of this gene in our mouse panel was mediocre, and as shown in Fig 6A , the raw (non-normalized) data for B2M in our mouse muscle dataset does appear to suggest a highly significant (P = 0.0002) increase in B2M expression in dystrophic tissue.
At the household level, out of 306 HH visited, 40 HH had at least one positive animal (13.07%) and the p value between HH in the two states was highly significant ( p = 0.0002).
In the extended model (Supplement Table 7), the significance level of β-blockers changed from non-significant ( p = 0.1205) to highly significant ( p = 0.0002) with an HR of 1.004.
Association between development of disease and having ⩽50% of lymphocytes of resistant strain origin, and resisting disease and having >50% of lymphocytes of resistant strain origin, was highly significant ( P = 0.0002 by Fisher's Exact Test).
In contrast, the reduction in leukocyte counts was highly significant (P = 0.0002, F = 6.11) at the 0.05 level.
In addition, there was a highly significant difference in the survival rates of the mice treated with four-times injection with KMRC011 ( P = 0.0002), one-time injection with KMRC011 ( P = 0.07), and two-times injection with KMRC011 ( P = 0.009) compared with control) (Fig. 1 ).
Cox regression with clustering on pedigree showed that the exon was a highly significant predictor (χ 2 19.75 with 3 degrees of freedom, p = 0.0002).
Results Participants characteristics The PIR exhibited a highly significant correlation with the risk of DR ( P = 0.0002).
The second strongest signal identified in the GWAS, observed at rs12506228, showed two independent replications and the meta-analysis for replication studies was highly significant ( p = 2.0 × 10E-4).