“highly significant”

The model utilizing only data preprocessing without residual block optimization yielded a relatively lower accuracy of 75.68%, demonstrating a highly significant difference compared to the complete model ( p = 0.00013).

In particular, BAP1 was highly significant ( P = 0.00013, HR = 2.20, 95% CI: 1.47–3.29, more than 53 mutated tumours out of 888 total), with mutations associating with detrimental outcome in four tumour types and notable associations in KIRC ( P = 0.00079), consistent with a recent report 28 , and in UCEC ( P = 0.066).

In contrast, CAST 2959 and CAPN1 4751 exhibited the strongest evidence of LD among all marker pairs, with an intermediate D′ value (0.4731), low but higher r 2 (0.0851), and a highly significant chi-square result (χ 2 = 14.642, p = 0.00013).

The enrichment of these MCTS1 pLOF variants in our male MSMD cohort without genetic diagnosis ( n = 422, 5 pLOF variants) relative to a cohort comprising both male patients without mycobacterial infections and healthy male individuals ( n = 1,932, 0 pLOF variants) was highly significant ( p = 0.00013).

A highly significant association between the categorical PD-L1 TPS assessed by IHC and the continuous GEP-derived PD-L1 (CD274) was identified ( p = 0.00013).

All findings were highly significant following multiple comparison corrections ( p < .00013).

Aligned rank transform three-way ANOVA analysis revealed significant effects of session and experimental day, and further demonstrated a highly significant interaction between group (TMP versus vehicle) and session (A, D, A*; P = 1.3 × 10 −4 ), indicating that cell ablation significantly but differentially affected learning in novel and familiar sessions (Fig. 5e ).

The differences in the proportion of identified heterospecific song types between sympatric and allopatric Thrush Nightingale males were highly significant (GLM, DF1 = 1, DF2 = 15, F = 25.94, p = 0.00013), as was the difference in the proportion of Common Nightingale song types in repertoires of sympatric Thrush Nightingale and Common Nightingale males (GLM, DF1 = 1, DF2 = 15, F = 14.56, p = 0.0016).

The difference was highly significant in this case ( p = 0.00013). 3.2.

In the second stage, SNPs/loci that passed a significant threshold (p < 0.05) were further pruned down with bonferroni correction and only those SNPs that were highly significant (p < 0.00013, Supplementary Table 3 ), and belonged in particular, to the extracellular matrix (ECM) i.e., Aggrecan and Fibulin-1 genes were selected for genotyping, as these genes were up-regulated and associated with aPWV in the gene profiling work.

The difference was highly significant ( χ 2 = 14.6, P = 0.00013).

72 kDa type IV collagenase precursor was highly significant (FC > 2; p = 0.00013).

A highly significant association was found between reporting of complaints and occurrence of pulmonary complications at some point in the study (X2 (1, N = 250) = 14.6309, p = .000131) as shown in Table 3 .

Without exception, a highly significant difference was observed using every deleteriousness metric with M-CAP the most significant ( p = 1.37 × 10 − 4 ) all of which would withstand correction for the three independent tests performed.

When comparing these two groups, their 4YR IQ difference was highly significant (C/R, p = 1.379 × 10 –4 ; Figure 1a , middle panel).

These proportions were tested by a χ 2 test and were found to be highly significant ( P = 0.00014).

No significant differences were observed amongst viral strains at 4 dpi or 17 dpi, but highly significant differences in RNA1 (** p = 0.00014) and RNA2 (**** p = 0.0000008) were observed when comparing wildtype GHu to mutant GHu 1E Pol*/Sd K802G at 26 dpi, as shown by Tukey’s HSD test (Supplementary Fig. 6b,c).

Time effect The Friedman rank sum test showed a highly significant time effect for all tested individuals’ serum RELN concentrations ( p = 0.00014; d f = 7; χ 2 = 29.09).

Table 4 and Figure 8c list the 20 most significant small molecules along with their enrichment scores and p values; amongst these, Prestwick-1080 (enrichment score: −0.906) and verteporfin (enrichment score: −0.903) had highly significant negative scores (P = 0.00014 and 0.00176, respectively), suggesting they could restore the normal cell state.

We observed a highly significant negative correlation between ξ and the proportion of small distances Ψ ξ generated by the A-WE model ( r 2 = 0.969, P = 0.00014): the smaller ξ , the better the simulations fitted the observed data, and the greater the enrichment of the A-WE model in these simulations.

Both cell types showed highly significant effects on cyst volumes ( p = 0.00014, f = 14.7, df = 2,19), with no significant difference between rats treated with hNESCs and hNPCs.

This frequency approached significance in males (95% CI: 0.758-53.32, P =0.074), but was highly significant in females (95% CI: 3.852-Inf, P =0.00014) and when both sexes were combined (95% CI: 2.993-140.6, P =6.24×10 −5 ).

Correlation analysis of velocity and activation area within individual experiments revealed a highly significant correlation between these parameters both in acute experiments (Spearman r = −0.576, p = 0.00014), and in chronic experiments (Spearman r = −0.371, p = 0.043), particularly under isoflurane anesthesia (Spearman r = −0.526, p = 0.030).

Increase in waist circumference (cm) was another highly significant risk factor unique to COVID-19 risk of death (HR = 1.059 [1.028,1.091], p = 0.00014).

P levels were highly significant ( p < 0.00014); thus, the reliability of data was accepted and MANOVA was performed for both genders for each one of the two parameters, i.e., number of graphemes and BHK score. 3.2.