“highly significant”

The observed mean body weight ranged from 1.19 to 1.43 kg with highly significant (p < 0.0001) differences between districts and sex effects for all other morphometric traits.

Moreover, Spearman r always resulted higher than 0.8, confirming a highly significant direct correlation between specimens (Figures 3(c) and 3(d) , nonparametric Spearman correlation, p < 0.0001).

Next, we measured brain weight and found a highly significant difference ( t (40) = 10.08, p < 0.0001), where 3xTg-AD mice have a lower brain weight than NonTg counterparts.

It is noteworthy that all the 64 MDR cases were exclusively found among the retreated patients, bringing the proportion of MDR isolates in this group to 77.1% the difference of drug resistance between new versus retreated cases being highly significant ( P value < 0.0001).

Construct validity of the DFS-A Scale The exploratory factor analysis of the DFS-A scale showed a KMO measure of 0.92 indicating adequate sampling adequacy and a highly significant Bartlett’s Test of sphericity (χ 2 = 3205.10, df = 190, p value < 0.0001).

The model was highly significant ( F = 153.81, p < 0.0001) with a non-significant lack-of-fit ( p = 0.7526), indicating adequate fit.

Second, we explored regulations of serum protein levels over time, which revealed 34 highly significant positively and 39 highly negatively correlated proteins ( P ‐value < 10 −4 ; Fig 3C , Dataset EV6 ).

A one-way ANOVA revealed a highly significant effect of formulation on swelling (S w ) (F(7, 792) ≈ 43,176, p < 0.0001), with a very large effect size (η2 ≈ 0.997).

The activity of AMPs and Tobramycin against preformed biofilms resulted to be similar in 5 out of 6 strains tested, causing a highly significant reduction of biofilm viability compared to the controls (biofilm not exposed; p < 0.0001), regardless of the concentrations tested (Figure 3 ).

This association is highly significant ( p < 0.0001) when compared to a simulated random-breakage model.

The expression of Ki-67 Li and inflammatory cells were highly significant ( P < 0.0001).

The two-way interaction of the condition and the surface was also highly significant ( p -value < 0.0001), indicating that polishing increased the microhardness values at the top and the bottom surface.

Nonparametric one-way ANOVA with repeated measures design by ranks (Friedman tests) revealed highly significant changes during the oGTT (AcG: p < 0.0001; UnG: p = 0.0007; ratio: p = 0.0087), but as specified by post-hoc Dunn’s Tests, in contrast to our expectations, we did not observe a strong decrease in circulating ghrelin levels after glucose ingestion.

The overall across-population difference in CYP2C8 allele frequencies was highly significant for three polymorphic variants (rs11572080 [* 3 ], rs11572103 [* 2 ], rs10509681 [* 3 ]; p <0.0001).

A multivariate analysis adjusted for etiology, site, age, and weight in comparison with ideal weight showed that in both young children and in the older population, time spent with plasma FVIII <1 IU/dL was a highly significant predictor of the rate of all bleeding ( P <0.0001 for young children; P <0.05 for older patients) and the rate of joint bleeds ( P <0.0001 for young children; P <0.02 for older patients).

DcR3 concentrations between sepsis (10.46 ± 1.46 ng/mL) and SIRS (2.06 ± 0.33 ng/mL) showed a 5.1-fold difference, which was highly significant ( P < 0.0001).

The two‐way ANOVA on square‐root arcsine transformed data showed highly significant effects of dose ( F 1,32 = 26.79, p < .0001) and of the interaction between dose and accession ( F 1,32 = 20.39; p < .0001), but not of accession ( F 1,32 < 0.42; p = .52), and the residuals from this model did not deviate from normality ( W = 0.95, p > .12).

No correlations were found between SREBF2 and HMGCS1 , HMGCS2 ( Figures 2E, F ), or with PPARG ( Figure 2H ), but a highly significant correlation was found with PPARGC1A ( Figure 2G , P < 0.0001).

The absence of Tardbp 2lox/2lox offspring was highly significant (p<0.0001, Chi-square test); the ratio of Tardbp +/+ to Tardbp +/2lox mice (22∶49) fit the expected 1∶2 ratio, consistent with a purely recessive inheritance lethality in the homozygote.

All pair wise distances were highly significant ( p < 0.0001).

The analysis of variance of the response surface quadratic regression model showed that the model was highly significant ( p < 0.0001) with a high F-value of 32.31.

For the 2- to 12-year-olds, the 40 factors showed highly significant group differences ( P < 0.0001).

The Spearman rank correlation was highly significant ( ρ = 0.77 , p < .0001 ) indicating strong similarity between the two variables.

The analysis revealed a highly significant effect of sample source on Vibrio detection ( χ 2 = 38.78, df = 3, adjusted p < 0.0001).

The results showed a significant enhancing effect of MEP in the affected hemisphere (SMD = 0.38, 95% CI = 0.02–0.74; P = 0.04) without heterogeneity ( I 2 = 0%) ( Figure 4(a) ) and a highly significant suppressing effect of MEP in the unaffected hemisphere (SMD = −0.83, 95% CI = −1.13 to −0.54; P < 0.0001), without significant heterogeneity ( I 2 = 18%) ( Figure 4(b) ). 3.3.2. rMTs in Both Hemispheres Four studies ( N = 121) [ 26 , 28 , 32 , 34 ] assessed the effect of LF-rTMS on rMT of the affected hemisphere by using the fixed-effect model that showed a large suppressing effect size (SMD = −1.00, 95% CI = −1.90 to −0.11; P = 0.03; I 2 = 79%) ( Figure 4(c) ).