“highly significant”

By correlating the immunohistochemical results with clinicopathological data, we demonstrated a highly significant correlation of NRF2 high and AKR1C3 high tumors with worse overall survival (OS) ( p < 0.0001 and p < 0.001, respectively) ( Table 1 and Table S1 ).

Results showed a highly significant 46.15-fold increase of RHOB expression in 3D versus 2D ( p = 0.0001) ( Figure 5 A, Table S1 ).

Differences between the three groups were highly significant ( n = 7, p < 0.0001 among three groups). 3.2.

FPOS was highly significant in race and combined models ( Table 4 and Table S1 , referent comparisons p < 0.0001 to p = 0.0133).

The conclusion about the difference in the richness of ground cover species under the different tree dominant canopies remains highly significant (P < 0.0001) for any block size (5 × 5, 10 × 10, or 20 × 20 m) in an ANOVA with mixed effects regarding the spatial connectivity of plots.

Statistical differences were determinated through the one-way analysis of variance procedure followed by Dunnett’s multiple comparison test, comparing results between mock control and treated cells, Differences were statistically significant when p < 0.05 (*) (#) and highly significant when p < 0.0001 (**) (##) versus each respective mock control or untreated control group. 3.

The main effects of both Relative Risk and Relative Negativity were highly significant (see Table 3 ), as were the simple effects for each language ( p < 0.0001 for the effects of both Relative Risk and Relative Negativity for both the native and foreign language).

The model turned out to be highly significant at the permutation test ( p < 10 −4 ), as shown in Figure 9C , and predictive with 100% correct classification rate. 4 Discussion In the present study, the longitudinal multi-omics investigation on a single mother-infant dyad was proposed to examine in depth the relationships among diet composition, gut microbiota metabolism and composition during the transition from breastfeeding to weaning.

These differences were highly significant ( P < 0.0001).

These differences were highly significant ( P < 0.0001) (Fig. 5 ).

58 Our results revealed that the TT genotype and the T allele distribution were dominant in the HCC group rather than the CT and CC genotypes in the control group, with a highly significant difference between the two groups, P = 0.0001.

The correlation between NEPSY raw scores (Response set) and BMT- i auditory attention results (“conflict” task) was highly significant [ r = 0.71 (0.53–0.84); p < 0.0001].

Utilizing a custom microarray the correlation ( r = 0.87) between DIM and E 2 in modulation of hepatic gene expression in trout was highly significant ( p < 0.0001) ( 83 ).

Both analyses showed a highly significant correlation with a p -value of <0.0001 each.

p-Values were taken to be significant: *significant 0.05≥p>0.01; **very significant 0.01≥p>0.001; ***highly significant 0.001≥p>0.0001; ****highly significant p≤0.0001.

Interestingly, we also observed strong positive correlations of serum SFRP5 with circulating concentrations of adiponectin ( r = 0.55, p < 0.001) and this association remained highly significant in multiple regression analysis ( β = 0.50, p < 0.0001), whereas association between SFRP5 and insulin sensitivity was no longer significant after adjusting for serum adiponectin.

When removing these image pairs, the effect decreased, though it remained highly significant (incongruent images: M = 3.61, SD = 0.88; congruent images: M = 2.84, SD = 0.82, t (92) = 7.63, p < .0001).

The Pearson correlation coefficients between the two replications for TTKSK, TRTTF, and TTTTF were 0.90, 0.83, and 0.95, respectively, which were highly significant ( P < 0.0001), indicating high repeatability of the two replicates in the tests with each race.

Conversely, infection with Foxo1 AdV significantly reduced hepatocyte Fgf21 expression, whereas shFoxo1 AdV infection significantly increased Fgf21 mRNA ( Figure 3G ); as both viruses dose-dependently affected Fgf21, the expected linear trend in Fgf21 expression was also highly significant (p < 0.0001).

111 In–Match–AuNP–Tat also caused a highly significant upregulation of γH2AX foci/NSA in comparison to an untreated control (0.12 ± 0.04 versus 0.07 ± 0.03 μm –2 ; p < 0.0001) and to 111 In–Scramble–AuNP–Tat (0.12 ± 0.04 versus 0.07 ± 0.03 μm –2 ; p < 0.0001).

The number of BUNV isolates was strikingly increased in these cells with 84% ( n = 42) ( Figure 2 C) of all plaque isolates having a BUNV wt genome; Fisher’s exact test revealed a highly significant difference ( p < 0.0001) in comparison to U4.4 cells.

The highly significant ( p < 0.0001) genotype × year interaction also indicated the major influence of environment on the traits ( Supplementary Table S4 ).

Moreover, a negative correlation between TP and circulating CREA (ρ = −0.540; p = 0.004), which in turn markedly correlated with ALT and moderately with UREA in a negative and highly significant way [(ρ = −0.703; p < 0.0001) and (ρ = −0.560; p < 0.0001), respectively] was found.

Comparing the results of retinal thickness values measured in the whole macular area (6 × 6 mm) and fovea (automatically selected by the instrument software) we also observed highly significant differences between the groups: the whole macular area ( p < 0.0001) and fovea ( p = 0.02).

We stratified analyses by sex as it was a highly significant effect modifier (p<0·0001).