“highly significant”

For all six species, it is lower in overall genomic DNA relative to protein coding DNA (this was highly significant for all six pairwise comparisons, p < 10 −4 , MWU‐test).

This was highly significant but represented only 0.55% of explained variance ( χ 2 ( df = 1, n = 4723) = 25.60, p < 0.0001, φ = 0.074).

Table 8 shows that based on Model 2 instead of Model 1, 16.5% of those developing a CVD event would have moved up to the 'high risk' category of ≥20% while of those not having a CVD event 9.4% would have moved to this risk category, the difference of which is highly significant (p < 0.0001).

Likewise we observed a highly significant (p < 0.0001) difference in mean survival time with an average of 102 months in the group of breast cancer patients who died of CCVD and an average of 61 months in the group who died of breast cancer.

Importantly, multivariable Cox analysis demonstrated that CCNF remained a highly significant predictor of OS independently of histologic grade and TNM stage (HR 2.86, 95% CI 2.02–4.06, p < 0.0001; Table 4 ).

Differences were highly significant compared with baseline ( P < 0.0001) and significant for the difference between systolic blood pressure values ( P = 0.011).

When entire metabolomic profiles are evaluated by use of principal component analysis, differentiation of cancerous and histologically benign prostate tissue samples has been shown to be highly significant (p<0.0001) with an overall accuracy >98%.

There was a highly significant direct correlation (Spearman's correlation coefficient r = 0.72; P < 0.0001) between the mean lesion size of the adenoma cases and the percentage of significant different texture features between adenomas and carcinomas.

There was a highly significant effect of basking position on the maximum body temperature reached ( F 2,86 = 998.8, P <0.0001) the greatest temperatures being reached with the most open wings ( Fig 3 ).

This association with the TSS and TES of expressed genes was highly significant (P<0.0001, Fig. 3D ).

The effect of the choice of parameter set on the number of backbone hydrogen bonds, the number of native backbone hydrogen bonds, the polar and nonpolar SASA, the radius of gyration, RMSD 100 , and the proportions of α-helix and β-strand was highly significant, with p < 0.0001.

In addition, the difference between this specific distribution of TbMlp2 and a random distribution of centromeres in the nucleus was highly significant ( P < 10 −4 ).

All the main and interaction effects were observed to be highly significant ( p < 0.0001).

The fold changes of qPCR and microarray analysis showed a highly significant Spearman correlation of r = 0.804 (p<0.0001).

The earlier trial also found no difference in walking speed (effect size = 0.00 [−0.08, 0.08]) 9 , 11 but did report a highly significant increase ( P = .0001) in FAC score from a median of 1 (1-1) to 2 (1-2). 12 However, the earlier trial had a greater risk of potential bias than the one reported here for the following reasons: randomization was not to group but to the order of each individual using an AFO once the control walk (without AFO) had been made; observers were not masked to conditions because participants used the AFO during testing sessions; and an independent randomization service was not used.

sTREM1 was abnormal in 82 (59%) of the patients (mean ± SD 63.26 ± 54.58) and normal in 57 (41%) patients (15.35 ± 6.10), which is highly significant ( P < 0.0001) and correlates well with total leucocyte counts, which are (mean ± SD) 15,283 ± 6,126 for patients with abnormal sTREM1 and 13, 001 ± 6,518 for normal patients ( P < 0.05).

The geographic smooth term explained the largest proportion of total variance and was highly significant ( P < 0.0001) in all years.

As expected, induction of the p21 gene in the population was highly significant for all the treatments (p<0.0001).

Although the changes between individual phases (T1 through T5) did not reach statistical significance, the main effect of experimental phase was highly significant ( p < 0.0001).

Results in Table 2 show highly significant relative humidity effect on both D. minutus reproductive capacity (F=388.91, DF=4, 45; p<0.0001) and adult lifespan (F=464.70, DF=4, 45; p<0.0001).

H19, an oncogene in BC development, showed a highly significant decrease after treatment combination (Fig. 3 . i) (70.83%) ( p < 0.0001).

The Gompertz curve fitted to the entire data set was highly significant ( F = 5127.5, P > 0.0001, df = 2, 107) and accounted for 99% of the total variation in the data ( Table 2 ).

Overall duration of hospitalization was significantly high in fibrinolytic group, this was 17.6± 1.95 days versus 12.09± 2.18 days in open decortication group with highly significant p-value of <0.0001 ( Table-II ).

Notably, the combination treatment group (PLX3397 + shIDO-ST) exhibited a highly significant reduction in CD206 + F4/80 + cells compared to untreated tumors and single agent-treated tumors ( Figure 5F , p < 0.0001, ANOVA), indicating a potentially synergistic effect on reducing M2 TAMs.

This difference was already highly significant ( p < 0.0001).