“highly significant”

Statistical analysis (ANOVA) indicated a highly significant reduction in pain severity ( P < 0.0001) and related symptoms ( P < 0.0001) evaluated by Michigan Neuropathy Screening instrument, Total Symptom Score, and Neuropathic Pain Symptoms Inventory.

young mice Semiquantitative analysis of the burden of clustered immunoreactive puncta in the hippocampal formation of all 40 mice (i.e., 22 young and 18 aged mice) revealed a highly significant linear trend toward greater load in aged mice ( p < 0.0001 for each of LC3, p62, ubiquitin, MAP2, and synapsin IIa stainings; χ 2 test for linear trend [Fig. 3a–e ]).

Segregating the mice by sex exposed a 4.75-fold increase of Wnt signaling activity in male LRRK2 KO mice and a 4.66-fold increase of Wnt signaling activity in male LRRK2 G2019S KI mice with both effects being highly significant ( P < 0.0001; Fig. 2 B).

Specifically, rmpA , rmpA2 , and iucA showed the strongest associations, with absolute differences in reporting frequency exceeding 20 percentage points and highly significant statistical support ( p < 0.0001 for all comparisons).

The overall model was highly significant (F = 84.53, p < 0.0001), and the lack-of-fit test was not significant ( p = 0.4872), indicating good model adequacy.

A slight decreasing trend of malaria mortality was observed over the whole study period which is however highly significant (p = 0.0001).

There was a highly significant correlation between serum LBP and sCD14 (r=0.657, p<0.0001) (see online supplementary figure S1).

This association with the TSS and TES of expressed genes was highly significant (P<0.0001, Fig. 3D ).

Specifically, the low-dose group showed highly significant differences at both 12 h and 24 h ( p < 0.0001), whereas the high-dose group showed a significant effect at 12 h ( p < 0.0001) and a highly significant effect at 24 h ( p < 0.0001).

The analysis of variance also showed that the second order polynomial regression models are highly significant (p value < 0.0001) (Table 5 ).

Furthermore, time after collection was a highly significant factor contributing to stability in FGM concentrations for both assays (cortisol EIA, d.f. = 100, F = 6.17, P < 0.0001; and corticosterone RIA, d.f. = 100, F = 5.4, P = 0.0002).

The p -values indicated highly significant differences ( p < 0.0001) between the control and mixes 3−7 for anaerobic runs, and between the control and mixes 2−7 for aerobic runs.

For frailty in WHAS, the model form does not allow the calculation of a simple R 2 , but the effect of PCA1 remains highly significant with or without control for age ( p <0.0001), and declines from 0.146 to 0.104 frailty criteria.

The difference among the groups was highly significant ( χ 2 : 24.98; P <0.0001) ( Figure 1 ).

For MZ twins, the association between twins’ attachment security was highly significant (kappa = .26, χ 2 (1) = 19.86, p < .0001).

This was particularly evident for MSWC 30% and MIX 30% for which the correlation values between DOC and labile As were highly significant ( r = − 0.79, P < 0.0001 for MSWC 30%; r = − 0. 90, P < 0.000001 for MIX 30%).

When entire metabolomic profiles are evaluated by use of principal component analysis, differentiation of cancerous and histologically benign prostate tissue samples has been shown to be highly significant (p<0.0001) with an overall accuracy >98%.

The overall model was highly significant (F = 32.90, p < 0.0001), indicating that the selected operating variables explained a significant fraction of the variability in liquid yield.

Correlations of the HR with ambient temperature and heat index were also negative and very highly significant ( P < 0.0001) in both sexes of the AGRs.

The rate of perinatal death was found to be highly significant (p<0.0001) with the number of children a woman had in both survey rounds.

The interaction between the population origin and the applied treatment showed a highly significant effect (F = 59.88, p ≤ 0.0001), suggesting that the response to damage is significantly modulated by the genetic origin of the plants ( Table S4 ).

BM32 induced highly significant allergen-specific IgG responses (P < 0.0001) but no allergen-specific IgE.

Surprisingly, U-HO1-RS cells differ from U-HO1-PTPN1-RS-cells by a highly significant increase of very short telomeres including "t-stumps" (p < 0.0001).

However, some weakly significant correlations were seen between the T cell response and the IgG2 response, with one highly significant correlation at week 8 (r 2 = 0.14, p < 0.0001).

Similarly, there were also highly significant differences among the various time points (F = 109.57, P < 0.0001).