“highly significant”

The second validation step performed by MS-qPCR on core biopsies from 131, 59 and 36 patients with histologically diagnosed PCa, BPH and high-grade PIN, respectively, showed highly significant differences in the methylation status of the APC, TACC2, RARB, DGKZ, C5orf4 and HES5 regions between BPH and PCa ( P <0.0001).

sEnd increases persisted through C2D22 and EOS (data not shown), and were found to be highly significant ( P < 0.0001; r -squared = 0.84).

By contrast, the discovery cohort had a median of four (p10-p90: 1-6) and five (p10-p90: 2-9) mutations at the first and second samplings, respectively, representing a highly significant increase in the number of mutations during disease progression ( P <0.0001).

The wear rate showed a statistically highly significant difference between the two liners after 12 ( p < 0.0001), 18 ( p = 0.018) and 24 ( p = 0.002) months (Fig. 5 , Table 2 ).

Since no cell death can be observed in cerebellar slice cultures under control conditions, the cell death after OGD in this region is highly significant ( P < 0.0001) about 380 times higher ( Figure 1F ).

Looking at the association between BCR reactivity of DLBCL cells and the presence of hypophosphorylated Ars2 isoform overall, considering data from both cell lines and cases with cryospecimenderived recombinant Fab, the association was statistically highly significant (Fisher exact t -test: two-tailed P <0.0001).

Two-way ANOVA showed highly significant time-dependent block for all peptides compared to control ( p < 0.0001, F = 6.83, df = 9).

The model turned out to be highly significant at the permutation test ( p < 10 −4 ), as shown in Figure 9C , and predictive with 100% correct classification rate. 4 Discussion In the present study, the longitudinal multi-omics investigation on a single mother-infant dyad was proposed to examine in depth the relationships among diet composition, gut microbiota metabolism and composition during the transition from breastfeeding to weaning.

On the other hand, podocyte damage groups (MCD, FSGS, MGN and amyloidosis) showed a statistically highly significant upregulation of podocyte CD73 ( p < 0.0001); the significant increase was consistent also when comparing single entities with negative controls ( p at least < 0.001).

bovis challenged (C) animals, PPDb-induced ratios for IFN-γ, IL-2, and CXCL9 showed highly significant potential as single biomarkers ( p < 0.0001).

Marbling Score and REA The mean marbling score evaluated in both laboratories for the striploins of different experimental groups showed greater values for the CAB striploins than for the CTNA counterpart ( Table 1 ), with highly significant differences ( p < 0.0001).

41 Both endpoints demonstrated profoundly better results in the colchicine group than in the placebo group that were highly significant, and acetaminophen consumption was substantially lower in the colchicine group (P < .0001 for all outcomes). 41 Leung et al. took a similar approach in 2018. 42 Patients meeting the ACR criteria for symptomatic and radiographic knee OA, along with a positive response to the frequent knee pain quest

Then, a two-way ANOVA factorial analysis revealed that the clinical state of the patients’ plasmas tested (“steady state” versus “acute phase”) had a highly significant effect ( p < 0001) on PS-exposure quantification.

The seed viability ranged from 18% (E09) to 81% (N01), and there were a positive and highly significant relationships between seed germination and viability traits (r = 0.883; P < 0.0001).

Pooled analysis of all trials found a highly significant reduction in recurrence (RR 0·66, 95% CI 0·62 to 0·71; p<0·0001; figure 1 ) and breast cancer mortality (0·67, 0·61 to 0·73; p<0·0001; appendix p 7 ) with chemotherapy plus trastuzumab compared with chemotherapy alone.

The difference was also highly significant when the threshold was placed at 5% wound BSA (median 5.05 vs. 37.3 pg/mL, p < 0.0001) (Figure 2b ).

When also two studies with calcifediol were considered, the effect on PTH was highly significant ( P < 0.0001), but heterogeneity was substantial ( I 2 = 60%) (not shown).

Regarding the presence of atrial fibrillation, it was more commonly observed in patients with rheumatic etiology (31%) as compared to patients with non-rheumatic etiology (12%) with highly significant statistical difference ( p < 0.0001).

The use of ventilators for non-survivors (29.5%) was almost twice that given for the survivors (15.2%), and ICU admission was more than twice for those who died (21.2%) compared to that for the survivors (8.4%), both with a highly significant p -value ( p < 0.0001).

Highly significant effect ( p < 0.0001) of treatment and interaction on enzyme activity was recorded (Table 1 ).

Geographic differences were notable, with the proportion of individuals with probable PTSD ranging from 40.0% to 100% across divisions, yielding a highly significant difference (p < 0.0001), whereas divisions showed minimal variation (Minor vs Majors divisions PR 1.01, 0.64-1.61; p = 0.96); Figure 5 .

The rate of transcript reduction was highly significant ( P <0.0001) between the onset of the disease and day +22, between days +22 and +45, and between days +57 and +85.

According to the statistical analysis, highly significant differences ( p ≤ 0.0001) were determined among the studied IAS.

A three-way ANOVA illustrates that all individual factors except for temperature (ANOVA, p = 0.11, df = 2, 54) and all interactive factors had a highly significant influence on cell density ( p < 0.0001).

Among the genes associated with auditory abnormalities, in the cellular component domain, the most strongly enriched term was cytoplasm, with 67% of annotated genes and a highly significant adjusted p ‐value p < 0.0001.